INT348174

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.90
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (STAT3, IL23R) nucleoplasm (STAT3) DNA binding (STAT3)
cytoplasm (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3)
STAT3 (Homo sapiens)
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 82 99.76 Very High Very High Very High
cytokine 2 96.96 Very High Very High Very High
psoriasis 8 95.04 Very High Very High Very High
Multiple sclerosis 2 88.96 High High
rheumatoid arthritis 8 84.92 Quite High
Crohn's disease 30 63.44 Quite High
spondylitis 4 50.00 Quite Low
Inflammation 18 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ankylosing Spondylitis 84 99.76 Very High Very High Very High
Autoimmune Disease 4 96.56 Very High Very High Very High
Infection 2 95.52 Very High Very High Very High
Psoriasis 8 95.04 Very High Very High Very High
Disease 68 94.56 High High
Syndrome 2 92.40 High High
Demyelinating Disease 2 88.96 High High
Diabetes Mellitus 10 85.60 High High
Rheumatoid Arthritis 8 84.92 Quite High
Inflammatory Bowel Disease 50 48.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The STAT3 association is particularly significant because of its role, along with IL23R, in the Th17 pathway.
STAT3 Binding (association) of IL23R
1) Confidence 0.40 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.97 Pain Relevance 0.47
The association with IL12B is of particular interest given the associations of IL23R and STAT3 with AS.
STAT3 Binding (associations) of IL23R associated with spinal inflammation
2) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.93 Pain Relevance 0.29

General Comments

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