INT348180

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IL23R)
Anatomy Link Frequency
nucleus 1
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 99.54 Very High Very High Very High
Multiple sclerosis 1 82.88 Quite High
rheumatoid arthritis 4 78.84 Quite High
spinal inflammation 41 72.08 Quite High
psoriasis 4 67.60 Quite High
spondylitis 2 50.00 Quite Low
Crohn's disease 15 36.00 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1 90.88 High High
Autoimmune Disease 2 90.48 High High
Disease 34 88.48 High High
Infection 1 84.80 Quite High
Demyelinating Disease 1 82.88 Quite High
Diabetes Mellitus 5 79.52 Quite High
Rheumatoid Arthritis 4 78.84 Quite High
Ankylosing Spondylitis 42 72.08 Quite High
Psoriasis 4 67.60 Quite High
Inflammatory Bowel Disease 25 42.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In response to cytokine signaling through the IL-23R, STAT3 is activated by phosphorylation and is translocated to the nucleus where it acts as a transcriptional activator.
Localization (translocated) of IL-23R in nucleus associated with cytokine
1) Confidence 0.34 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.91 Pain Relevance 0.36

General Comments

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