INT348213

Context Info Confidence 0.32 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0

nucleoplasm (Akt2) transport (Akt2) mitochondrion (Akt2) carbohydrate metabolic process (Akt2) cytoplasm (Akt2) cytosol (Akt2)

Anatomy Link Frequency endothelial cells 1 Akt2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 9 5.00 agonist 9 5.00 anesthesia 4 5.00 isoflurane 2 5.00 ketamine 1 5.00 Potency 1 5.00 antagonist 1 5.00 Catecholamine 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 9 83.84 Myocardial Infarction 104 82.72 Cardiovascular Disease 4 67.20 Insulin Resistance 12 63.44 Hyperglycemia 4 61.60 Coronary Artery Disease 1 36.40 Body Weight 13 28.68 Targeted Disruption 3 12.96 Cv Unclassified Under Development 9 5.00 Weight Loss 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, endothelial cells had a substantial proliferative response to exenatide treatment and this response was mediated by activation of both the AKT2/eNOS and the PKA/PI3K signal transduction pathways.

Positive_regulation (activation) of AKT2 in endothelial cells

1) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.58 Pain Relevance 0

General Comments

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