INT34822

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2008
Negated 3
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 4.03
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
microglia 6
macrophage 2
myocardium 2
hepatocyte 2
brain 2
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 598 100.00 Very High Very High Very High
Paracetamol 13 99.46 Very High Very High Very High
agonist 66 96.48 Very High Very High Very High
Neuritis 9 95.76 Very High Very High Very High
dopamine receptor 8 72.56 Quite High
Potency 60 63.76 Quite High
Peripheral nervous system 1 59.32 Quite High
Inflammation 37 39.40 Quite Low
lidocaine 1 36.64 Quite Low
nMDA receptor antagonist 17 33.12 Quite Low
Disease Link Frequency Relevance Heat
Death 282 100.00 Very High Very High Very High
Toxicity 36 98.08 Very High Very High Very High
Disease 87 96.76 Very High Very High Very High
Necrosis 18 95.28 Very High Very High Very High
Diabetes Mellitus 6 95.16 Very High Very High Very High
Apoptosis 276 92.56 High High
Experimental Autoimmune Neuritis 9 91.00 High High
Immunization 2 87.64 High High
Neurodegenerative Disease 61 82.04 Quite High
Bacterial Respiratory Disease 8 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo effect of the D-(-) isomer or natural form of 3-hydroxybutyrate on initial release of lactate dehydrogenase from the acutely ischaemic myocardium.
Regulation (effect) of Localization (release) of lactate dehydrogenase in myocardium
1) Confidence 0.57 Published 1986 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 3746923 Disease Relevance 0.15 Pain Relevance 0
BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) at 40 microM markedly inhibited glutathione reductase and also strongly potentiated cell killing by AAP but did not significantly influence segmental cytoplasmic contraction or LDH release in response to AFB1.
Neg (not) Regulation (influence) of Localization (release) of LDH associated with paracetamol
2) Confidence 0.25 Published 1986 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3088775 Disease Relevance 0.28 Pain Relevance 0.71
The results from our investigation appear to demonstrate that the manzamine analogs clearly differed in their effect on LDH release from LPS-primed microglia: MZA, MZE and MZF generated less than 50% of maximal LDH release at 10 ?
Regulation (effect) of Localization (release) of LDH in microglia
3) Confidence 0.23 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1079881 Disease Relevance 0.23 Pain Relevance 0.17
The final concentration of DMSO did not affect microglia viability or LDH release.
Neg (not) Regulation (affect) of Localization (release) of LDH in microglia
4) Confidence 0.23 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1079881 Disease Relevance 0 Pain Relevance 0
Effect of manzamine E on LPS-activated neonatal brain microglia TXB2, O2- and LDH release
Regulation (Effect) of Localization (release) of LDH in brain
5) Confidence 0.17 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1079881 Disease Relevance 0 Pain Relevance 0.04
Effect of manzamine A on LPS-activated neonatal brain microglia TXB2, O2- and LDH release
Regulation (Effect) of Localization (release) of LDH in microglia
6) Confidence 0.17 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1079881 Disease Relevance 0.17 Pain Relevance 0.05
METHODS: We investigated the effect of incubation of rat hepatocytes and 3 hepatocyte cell lines with acetaminophen or N-acetyl-p-benzoquinoneimine on LDH release, glutathione status, mitochondrial function, CYP1A activity, albumin synthesis and DNA content.
Spec (investigated) Regulation (effect) of Localization (release) of LDH in hepatocyte
7) Confidence 0.13 Published 1999 Journal J. Hepatol. Section Body Doc Link 10580581 Disease Relevance 0.10 Pain Relevance 0
-E2 completely inhibited cell death and the release of LDH returned to control levels (data not shown).


Regulation (control) of Localization (release) of LDH associated with death
8) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.51 Pain Relevance 0.41
The medium was then changed and the effects of various concentrations (1–20 mM) of glutamate on lactate dehydrogenase (LDH) release were measured for 6 h.
Regulation (effects) of Localization (release) of LDH associated with glutamate
9) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.49 Pain Relevance 0.50
During this period, LDH release in untreated control cells remained the same for up to 8 h and significantly increased (P < 0.05) after 24 h (Figure 4).
Regulation (same) of Localization (release) of LDH
10) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.41 Pain Relevance 0.53
Linomide, however, does not affect macrophage death and release of lactate dehydrogenase.
Neg (not) Regulation (ffect ) of Localization (elease ) of lactate dehydrogenase in macrophage associated with death
11) Confidence 0.08 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9184648 Disease Relevance 0.90 Pain Relevance 0.71
In order to follow the kinetics of glutamate cytotoxicity, the effect of 5 mM glutamate on LDH release as a function of time was measured for up to 24 h.
Regulation (effect) of Localization (release) of LDH associated with glutamate
12) Confidence 0.07 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.44 Pain Relevance 0.53
AD, memantine was protective with IC50 of c.a. 1-2 µM against semi-chronic excitotoxicity (4-20 days) produced by low concentrations of 3-NP (35 µM) as measured as changes in LDH release [115].
Regulation (changes) of Localization (release) of LDH associated with disease
13) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.35 Pain Relevance 0

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