INT34830

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.99
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
myometrium 1
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 3 100.00 Very High Very High Very High
antagonist 74 99.96 Very High Very High Very High
dexamethasone 385 98.88 Very High Very High Very High
palliative 4 98.84 Very High Very High Very High
gABA 11 98.76 Very High Very High Very High
potassium channel 5 90.16 High High
Inflammation 21 88.00 High High
rapifen 7 87.52 High High
Pain 27 85.00 Quite High
agonist 39 81.60 Quite High
Disease Link Frequency Relevance Heat
Headache 4 100.00 Very High Very High Very High
Cancer 296 98.98 Very High Very High Very High
Breast Cancer 301 96.64 Very High Very High Very High
Multiple Myeloma 176 96.22 Very High Very High Very High
Aging 15 94.12 High High
Hemorrhage 16 93.36 High High
Uterine Fibroids 42 92.64 High High
Reprotox - General 1 27 92.64 High High
Endometriosis (extended) 21 91.80 High High
Apoptosis 54 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation time constant of the whole-cell potassium currents remained unaffected upon PR treatment, whereas both the rate and extent of the inactivation process were increased, indicating the "open channel block" mechanism.
Neg (unaffected) Regulation (unaffected) of PR
1) Confidence 0.45 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8781501 Disease Relevance 0 Pain Relevance 0.28
The aim of this study was to investigate the role of common polymorphisms in the estrogen receptor gene (ESR1) and the progesterone receptor gene (PGR) in the risk for migraine in a Spanish population.
Spec (investigate) Regulation (role) of PGR associated with migraine
2) Confidence 0.44 Published 2009 Journal Eur. J. Neurol. Section Abstract Doc Link 19175383 Disease Relevance 0.27 Pain Relevance 0.27
Interestingly, letrozole was effective even in marginally ER+ tumors and, unlike tamoxifen, consistently reduced the expression from estrogen-regulated genes (progesterone receptor and trefoil factor 1).
Regulation (regulated) of progesterone receptor associated with cancer
3) Confidence 0.37 Published 2007 Journal Breast Cancer Res Treat Section Abstract Doc Link PMC2001223 Disease Relevance 0.47 Pain Relevance 0
Similarly, ibandronate did not affect the baseline level of progesterone receptor and did not interfere with E2-induced expression of this receptor.
Regulation (affect) of progesterone receptor
4) Confidence 0.30 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0.26 Pain Relevance 0
These effects, discussed in more detail below, are likely to reflect target tissue specific manifestation of PR modulation that affects downstream pathways of PR, ER AR and most likely other, still unidentified pathways.
Regulation (affects) of PR
5) Confidence 0.28 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 1.05 Pain Relevance 0
Efficacy of the progesterone receptor antagonist mifepristone for palliative therapy of patients with a variety of advanced cancer types.
Regulation (Efficacy) of progesterone receptor associated with cancer, antagonist and palliative
6) Confidence 0.27 Published 2010 Journal Anticancer Res. Section Title Doc Link 20332480 Disease Relevance 0.28 Pain Relevance 0.24
Our objective was to examine the topology-, gestation- and labor-related changes of estrogen receptor (ER)alpha, progesterone receptor (PR), oxytocin receptor (OTR) and thrombospondin-1 (TSP1) mRNA in pregnant baboon myometrium.
Regulation (changes) of PR in myometrium
7) Confidence 0.26 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0
To improve the value of ER determinations for tumor prognosis, tests for the presence of the estrogen-regulated PR protein are routinely performed.
Regulation (regulated) of PR associated with cancer
8) Confidence 0.25 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.80 Pain Relevance 0
Significant dose effects were observed for EP amplitude during but not beyond the distributional t1/2 of the drug, but significant effects on the PR extended beyond this time point.
Regulation (effects) of PR
9) Confidence 0.24 Published 1986 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3089670 Disease Relevance 0.09 Pain Relevance 0.62
This review summarizes mainly the prognostic values of classical (Ki67, ER, PR, HER2) and novel molecular factors (p53, p14ARF, cyclin D1, cyclin E, TBX2/3, BRCA1/2, and VEGF) for breast cancer.
Regulation (values) of PR associated with breast cancer
10) Confidence 0.15 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.19 Pain Relevance 0
These effects, discussed in more detail below, are likely to reflect target tissue specific manifestation of PR modulation that affects downstream pathways of PR, ER AR and most likely other, still unidentified pathways.
Regulation (modulation) of PR
11) Confidence 0.15 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 1.04 Pain Relevance 0
-TH PROG), are able to influence the synthesis of myelin proteins under the control of classical receptors (PR, progesterone receptor) and non classical receptors (GABA-A).
Regulation (control) of PR associated with gaba
12) Confidence 0.09 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.39 Pain Relevance 0.21
For example, more of 25% of chemicals annotated to estrogen receptor 1 (ESR1) affects also progesterone receptor (PGR).
Regulation (affects) of progesterone receptor
13) Confidence 0.05 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.55 Pain Relevance 0.08
-TH PROG), are able to influence the synthesis of myelin proteins under the control of classical receptors (PR, progesterone receptor) and non classical receptors (GABA-A).
Regulation (control) of progesterone receptor associated with gaba
14) Confidence 0.04 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.39 Pain Relevance 0.21
In a phase II study of 72 patients (median age 63 years) with newly diagnosed MM, induction therapy with clarithromycin 500 mg twice -daily, lenalidomide 25 mg/day on days 1–21 of a 28-day cycle, and dexamethasone 40 mg/day once weekly was associated with an objective response of PR or better in 65 (90.3%) patients (90.3%), including a CR rate of 38.9%.87 Fifty-three patients (73.6%) achieved at least a 90% decrease in M-protein levels.
Regulation (response) of PR associated with multiple myeloma and dexamethasone
15) Confidence 0.01 Published 2010 Journal Core evidence Section Body Doc Link PMC2899783 Disease Relevance 0.22 Pain Relevance 0.42

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