INT34834

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Context Info
Confidence 0.65
First Reported 1986
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh1) extracellular region (Ghrh, Gh1) cytosol (Gh1)
signal transduction (Gh1) mitochondrion (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
hypothalamus 2
Ghrh (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 25 99.88 Very High Very High Very High
Somatostatin 6 92.20 High High
agonist 1 49.16 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The demonstration that GH-releasing factor (GRF) stimulates GH synthesis and release in rat pups prompted studies to evaluate the effects on the same indices of clonidine (CLO), an alpha 2-adrenoceptor and potent GH secretagogue, purported to act in adult rats via GRF release.
GRF Positive_regulation (stimulates) of Gene_expression (synthesis) of GH associated with clonidine
1) Confidence 0.65 Published 1986 Journal Endocrinology Section Abstract Doc Link 3089765 Disease Relevance 0 Pain Relevance 0.53
These results indicate that 1) functional activation of alpha-2 adrenergic receptors by CLO increases GHRH release from the hypothalamus, 2) CLO, via GHRH, increases GH secretion and biosynthesis, which in turn feeds back in the hypothalamus to reduce GHRH biosynthesis, and 3) reduction of hypothalamic GH-stimulatory activity tones down the initial pituitary somatotropic hyperfunction.
GHRH Positive_regulation (increases) of Gene_expression (biosynthesis) of GH in hypothalamus associated with clonidine
2) Confidence 0.34 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.87

General Comments

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