INT348380

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.45 Pain Relevance 1.25

mitochondrion (Fdps) nucleolus (Fdps) peroxisome (Fdps) nucleus (Fdps) signal transducer activity (Lpar5) cytoplasm (Fdps)

Fdps (Rattus norvegicus) Lpar5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hyperalgesia 10 98.84 Pain 26 97.20 dorsal root ganglion 2 95.72 Inflammatory mediators 2 92.32 cytokine 4 89.68 bradykinin 4 89.12 Inflammation 4 84.24 Central nervous system 6 53.36 Neuropathic pain 4 50.72 substance P 6 47.08

Disease Link Frequency Relevance Heat Hyperalgesia 12 98.84 Pain 28 97.20 Ganglion Cysts 2 95.72 INFLAMMATION 6 91.92 Nociception 6 85.08 Neuropathic Pain 6 50.72 Inflammatory Pain 2 39.20 Apoptosis 2 31.44 Urological Neuroanatomy 18 5.00 Stress 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, FPP may not interact with GPR92 in a typical receptor-ligand manner.

FPP Neg (not) Binding (interact) of GPR92

1) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.64 Pain Relevance 0.56

Recent data indicated that FPP acts as a ligand of GPR92/LPA5 [23], suggesting an underlying mechanism for FPP in relation to pain.

FPP Binding (ligand) of GPR92 associated with pain

2) Confidence 0.06 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.81 Pain Relevance 0.69

General Comments

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