INT348381

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.75 Pain Relevance 0.64

mitochondrion (Fdps) nucleolus (Fdps) peroxisome (Fdps) nucleus (Fdps) signal transducer activity (Lpar5) cytoplasm (Fdps)

Fdps (Rattus norvegicus) Lpar5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 13 99.92 Hyperalgesia 5 94.64 Inflammatory mediators 1 88.12 cytokine 2 85.48 bradykinin 2 84.92 Inflammation 2 80.04 dorsal root ganglion 1 71.76 Neuropathic pain 2 46.52 substance P 3 42.88 IPN 1 35.00

Disease Link Frequency Relevance Heat Pain 14 99.92 Hyperalgesia 6 94.64 INFLAMMATION 3 87.72 Nociception 3 80.88 Ganglion Cysts 1 70.80 Neuropathic Pain 3 46.52 Inflammatory Pain 1 35.00 Apoptosis 1 27.24 Urological Neuroanatomy 9 5.00 Stress 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of GPR92/LPA5 by FPP increases IP production, cAMP levels, and Ca2+ levels in a concentration-dependent manner.

FPP Positive_regulation (Activation) of GPR92

1) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.75 Pain Relevance 0.64

General Comments

This test has worked.