INT348395

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0.42

mitochondrion (Fdps) nucleolus (Fdps) peroxisome (Fdps) nucleus (Fdps) cytoplasm (Fdps)

Fdps (Rattus norvegicus)

Pain Link Frequency Relevance Heat Antinociceptive 2 98.86 antinociception 1 97.40 cytokine 2 95.64 bradykinin 2 95.08 central sensitization 1 71.44 Central nervous system 3 65.68 Central grey 8 56.64 Pain 13 53.04 medulla 8 48.52 midbrain 8 47.96

Disease Link Frequency Relevance Heat Heart Disease 1 89.92 Hypertension 1 89.20 Urological Neuroanatomy 9 77.28 Nociception 3 67.68 Pain 14 53.04 Hyperalgesia 6 41.44 Peripheral Neuropathy 1 38.48 INFLAMMATION 3 36.40 Stress 2 35.20 Neuropathic Pain 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the antinociceptive effect of Statins also appears to be tightly related to reducing the production of FPP in that exogenous malvonate, the precursor of FPP, reversed the antinociception by Statins in the same study.

Negative_regulation (reducing) of Gene_expression (production) of FPP associated with antinociception and antinociceptive

1) Confidence 0.16 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.49 Pain Relevance 0.42

General Comments

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