INT348402

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs2) transport (LPA) small molecule metabolic process (LPA)
endoplasmic reticulum (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
sensory neurons 2
LPA (Homo sapiens)
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 13 99.82 Very High Very High Very High
IPN 1 98.56 Very High Very High Very High
Neuropathic pain 2 93.24 High High
substance P 3 90.44 High High
Inflammation 2 6.64 Low Low
Central grey 8 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 14 99.82 Very High Very High Very High
Inflammatory Pain 1 98.56 Very High Very High Very High
Apoptosis 1 96.20 Very High Very High Very High
Neuropathic Pain 3 93.24 High High
Nociception 3 91.84 High High
INFLAMMATION 3 6.64 Low Low
Urological Neuroanatomy 9 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overwhelming evidence points to the function of LPA in pain because LPA (1) stimulates cyclooxygenase-2 expression (COX-2) [13], which contributes to inflammatory pain; (2) increases reactive oxygen species (ROS) release [14], which is involved in the development and maintenance of neuropathic pain [15]; (3) induces nociception-producing activity and substance P release on sensory neurons [16]; and (4) is involved in the initiation of neuropathic pain [3,17,18]
LPA Positive_regulation (stimulates) of Gene_expression (expression) of cyclooxygenase-2 in sensory neurons associated with nociception, pain, ipn, neuropathic pain and substance p
1) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 0.62 Pain Relevance 0.48

General Comments

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