INT348479

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0

cytosol (CASP10) peptidase activity (CASP10) plasma membrane (CASP10)

CASP10 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 3 5.00 cytokine 2 5.00 alcohol 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 136 95.64 Infection 26 78.48 Shigella Infection 3 65.68 Repression 4 39.04 Cancer 8 5.00 Death 6 5.00 Sprains And Strains 4 5.00 Retinoblastoma 3 5.00 Necrosis 3 5.00 INFLAMMATION 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since S. flexneri inhibits caspase-3 activation despite cytochrome c release in the presence of STS, caspase-10 could be a eukaryotic target for the bacteria to utilize to interfere with caspase-3 activation and inhibit apoptosis.

Localization (presence) of caspase-10 associated with apoptosis

1) Confidence 0.13 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.32 Pain Relevance 0

General Comments

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