INT348542

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (BCL2, NLRP1) cytoplasm (BCL2, NLRP1) cytosol (BCL2, NLRP1)
nucleus (BCL2, NLRP1) mitochondrion (BCL2) cell morphogenesis (BCL2)
Anatomy Link Frequency
epithelial cell 2
BCL2 (Homo sapiens)
NLRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 95.76 Very High Very High Very High
cytokine 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 12 100.00 Very High Very High Very High
Apoptosis 408 99.74 Very High Very High Very High
INFLAMMATION 9 95.76 Very High Very High Very High
Death 18 92.88 High High
Cancer 24 33.84 Quite Low
Infection 78 8.88 Low Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Retinoblastoma 9 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low
Shigella Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While it may not be the primary method of apoptosis inhibition, NALP1 repression or inhibition of NALP1 by BCL-2 may be an important mechanism for the pro-survival state of the infected epithelial cell in the presence of STS.
BCL-2 Negative_regulation (repression) of NALP1 in epithelial cell associated with repression and apoptosis
1) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.70 Pain Relevance 0.04
NALP1 is suppressed by BCL-2 and BCL-XL to reduce caspase-1 activation and IL-1?
BCL-2 Negative_regulation (suppressed) of NALP1
2) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.63 Pain Relevance 0.05
While it may not be the primary method of apoptosis inhibition, NALP1 repression or inhibition of NALP1 by BCL-2 may be an important mechanism for the pro-survival state of the infected epithelial cell in the presence of STS.
BCL-2 Negative_regulation (inhibition) of NALP1 in epithelial cell associated with repression and apoptosis
3) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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