INT34859

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Context Info
Confidence 0.34
First Reported 1986
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
hearts 2
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 10 99.32 Very High Very High Very High
Analgesic 4 75.00 Quite High
Inflammation 3 75.00 Quite High
anesthesia 1 74.40 Quite High
cINOD 3 73.04 Quite High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 9 99.32 Very High Very High Very High
Anaphylaxis 2 84.32 Quite High
Hemorrhage 1 82.24 Quite High
Hypersensitivity 1 75.44 Quite High
INFLAMMATION 3 75.00 Quite High
Increased Venous Pressure Under Development 1 73.24 Quite High
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of the LTC4 is significantly enhanced at 1, 6 and 48 hours after SAH induction.
Positive_regulation (enhanced) of Localization (release) of LTC4 associated with cva
1) Confidence 0.34 Published 1994 Journal Neurochem. Res. Section Abstract Doc Link 7969754 Disease Relevance 0.88 Pain Relevance 0.48
High concentrations of the acidic drugs phenylbutazone and oxyphenbutazone as well as of the nonacidic metabolites of metamizol, i.e. 4-methylaminoantipyrine and 4-aminoantipyrine, inhibited the release of the cyclo-oxygenase products of arachidonic acid metabolism, TXB2 and 6-keto-PGF1 alpha, and simultaneously increased the release of LTC4-like immunoreactivity in hearts.
Positive_regulation (increased) of Localization (release) of LTC4-like in hearts
2) Confidence 0.03 Published 1986 Journal Agents Actions Suppl. Section Abstract Doc Link 3092600 Disease Relevance 0.38 Pain Relevance 0.22

General Comments

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