INT3486

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Context Info
Confidence 0.47
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.65
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 5 99.20 Very High Very High Very High
narcan 3 98.92 Very High Very High Very High
Clonidine 1 87.80 High High
Inflammatory mediators 18 86.00 High High
local anesthetic 1 82.08 Quite High
Opioid 1 82.04 Quite High
Catecholamine 1 81.08 Quite High
Inflammatory marker 1 80.92 Quite High
Enkephalin 1 80.44 Quite High
antagonist 2 77.88 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 16 100.00 Very High Very High Very High
Hyperinsulinism 10 100.00 Very High Very High Very High
Diabetes Mellitus 18 99.84 Very High Very High Very High
Overweight 8 99.84 Very High Very High Very High
Metabolic Syndrome 14 99.68 Very High Very High Very High
Obesity 163 99.54 Very High Very High Very High
Weight Loss 5 99.20 Very High Very High Very High
Pulmonary Disease 95 99.00 Very High Very High Very High
Chronic Disease 4 96.40 Very High Very High Very High
Ovarian Cancer 1 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obese subjects displayed an increased insulin response to oral and i.v. glucose load, due to an increased first phase of insulin secretion (phi 1), a reduced insulin sensitivity (Si) and glucose effectiveness (Sg) in respect to normal-weight subjects.
Positive_regulation (increased) of Regulation (response) of insulin associated with obesity and hyperinsulinism
1) Confidence 0.47 Published 1994 Journal Horm. Metab. Res. Section Abstract Doc Link 8082873 Disease Relevance 0.43 Pain Relevance 0.35
In diabetics, acute insulin responses to glucose were significantly increased by all the agents tested (naloxone, phentolamine and lysine acetylsalicylate), but only the cyclooxygenase inhibitor significantly augmented second phase insulin secretion and glucose disappearance rates.
Positive_regulation (increased) of Regulation (responses) of insulin associated with diabetes mellitus and narcan
2) Confidence 0.46 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3936737 Disease Relevance 0.68 Pain Relevance 0.21
Insulin secretion was evaluated as the suprabasal AUCins0–120, representing the glucose stimulated insulin response.
Positive_regulation (stimulated) of Regulation (response) of insulin
3) Confidence 0.40 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1635051 Disease Relevance 0.16 Pain Relevance 0.03
Additionally, obesity and the presence of metabolic syndrome are related to increased insulin resistance in overweight and obese COPD patients [59, 60].
Positive_regulation (increased) of Regulation (resistance) of insulin associated with pulmonary disease, obesity, metabolic syndrome, insulin resistance and overweight
4) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 2.38 Pain Relevance 0.18
cells, and, following initially increased insulin sensitivity, there follows a progressive increase in insulin resistance throughout the second and third trimesters (Butte 2000).
Positive_regulation (increased) of Regulation (sensitivity) of insulin associated with hyperinsulinism and insulin resistance
5) Confidence 0.13 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.42 Pain Relevance 0
Neither d- nor dl-propranolol induced any significant change in basal glucose or insulin levels before glucose administration.
Neg (Neither) Positive_regulation (induced) of Neg (Neither) Regulation (change) of insulin
6) Confidence 0.11 Published 1979 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 761441 Disease Relevance 0 Pain Relevance 0.08
In addition, the combination of weight loss and exercise in overweight individuals increases insulin sensitivity [16], PPARGC1A gene expression [17], and mitochondrial function [16].
Positive_regulation (increases) of Regulation (sensitivity) of insulin associated with weight loss and overweight
7) Confidence 0.10 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.43 Pain Relevance 0
A significant increase in insulin values was observed after dexamethasone administration (before: 120 +/- 10 micromol/l; after: 175 +/- 27 pmol/l; p<0.05), while glucose levels did not reach statistical significance (before: 4.6 +/- 0.3 mmol/l; after: 5.9 +/- 1.0 mmol/l).
Positive_regulation (increase) of Regulation (values) of insulin associated with dexamethasone
8) Confidence 0.09 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11817711 Disease Relevance 0.08 Pain Relevance 0.30
Black girls present higher insulin response to a glucose challenge, and subsequently increased levels of free IGF1, which is associated with skeletal and sexual maturation compared to white girls [36].
Positive_regulation (higher) of Regulation (response) of insulin
9) Confidence 0.04 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.05 Pain Relevance 0

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