INT34860

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Context Info
Confidence 0.30
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 0.97
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
neurons 10
medial 2
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 56 100.00 Very High Very High Very High
Somatostatin 51 99.48 Very High Very High Very High
Glutamate 123 98.44 Very High Very High Very High
Analgesic 4 95.52 Very High Very High Very High
substance P 33 90.08 High High
cINOD 3 87.68 High High
Inflammation 3 86.04 High High
antagonist 51 82.88 Quite High
Eae 25 73.32 Quite High
Neurotransmitter 285 60.00 Quite High
Disease Link Frequency Relevance Heat
Aging 7 99.98 Very High Very High Very High
Ganglion Cysts 31 94.40 High High
INFLAMMATION 3 86.04 High High
Hypersensitivity 1 82.36 Quite High
Anaphylaxis 2 80.00 Quite High
Targeted Disruption 16 58.28 Quite High
Congenital Anomalies 3 57.40 Quite High
Volume Depletion And Dehydration 1 50.96 Quite High
Disease 22 20.96 Low Low
Hypertension 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aging effects of SCN neuropeptide expression, like the circadian profile of peptide expression, may be species specific as far as the SCN is concerned.
Negative_regulation (effects) of Gene_expression (expression) of SCN associated with aging and neuropeptide
1) Confidence 0.30 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.16 Pain Relevance 0.74
In depressed patients, both synthesis and release of AVP in the SCN is reduced, which leads to an impaired functional activity of the circadian clock [187], although there was an increase in the number of AVP-immunoreactive neurons.
Negative_regulation (reduced) of Gene_expression (synthesis) of SCN in neurons
2) Confidence 0.26 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.06 Pain Relevance 0.04
Reduction of AVP neurons of the SCN has been reported to eliminate or reduce the amplitude of many rhythms studied.
Negative_regulation (Reduction) of Gene_expression (neurons) of SCN in neurons
3) Confidence 0.26 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0
Why does the SCN express and release such an abundance of neuropeptides?
Negative_regulation (does) of Gene_expression (express) of SCN associated with neuropeptide
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.05 Pain Relevance 0.19
PACAP enhanced AMPA-evoked currents recorded in mouse SCN neurons
Negative_regulation (recorded) of Gene_expression (neurons) of SCN in neurons
5) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.06 Pain Relevance 0.08
PACAP enhanced NMDA-evoked currents recorded in mouse SCN neurons
Negative_regulation (recorded) of Gene_expression (neurons) of SCN in neurons
6) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.06
PACAP enhanced excitatory synaptic transmission measured in mouse SCN neurons
Negative_regulation (measured) of Gene_expression (neurons) of SCN in neurons
7) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.15 Pain Relevance 0.17
Transient exposure to 6 h of darkness during the subjective day promotes arousal, suppresses c-Fos expression in the SCN and activates OXA-ir neurons, particularly those in the medial TH.
Negative_regulation (suppresses) of Gene_expression (expression) of SCN in medial
8) Confidence 0.10 Published 2008 Journal Mol Brain Section Body Doc Link PMC2632999 Disease Relevance 0.06 Pain Relevance 0.12
It remains to be investigated whether the partial inhibition of the synthesis of PGI2, a major hyperalgesiccyclo-oxygenase product of arachidonic acid metabolism, at lower concentrations of the active metamizol metabolites contributes to the analgesic effect of metamizol.
Spec (partial) Negative_regulation (inhibition) of Gene_expression (synthesis) of hyperalgesiccyclo-oxygenase product associated with analgesic
9) Confidence 0.01 Published 1986 Journal Agents Actions Suppl. Section Abstract Doc Link 3092600 Disease Relevance 0.45 Pain Relevance 0.55

General Comments

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