INT34862

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Context Info
Confidence 0.50
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.65
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (UBE4B) enzyme binding (UBE4B) cytoplasm (UBE4B)
Anatomy Link Frequency
feces 1
renal blood vessels 1
embryonic kidney 1
UBE4B (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 1 96.68 Very High Very High Very High
cINOD 2 75.00 Quite High
cytokine 6 46.92 Quite Low
headache 31 18.04 Low Low
Pain 3 13.88 Low Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 134 100.00 Very High Very High Very High
Leukocytosis 16 99.54 Very High Very High Very High
Infection 25 98.60 Very High Very High Very High
Fever 58 98.36 Very High Very High Very High
Vomiting 38 97.96 Very High Very High Very High
Syndrome 75 97.36 Very High Very High Very High
Disease 21 97.30 Very High Very High Very High
Depression 1 96.68 Very High Very High Very High
Meningitis 76 96.24 Very High Very High Very High
Renal Failure 1 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent data indicate that blood vessels have the capacity to synthesize the sulfidopeptide leukotrienes C4, D4, and E4, which can constrict peripheral and renal blood vessels and alter vascular permeability.
Gene_expression (synthesize) of E4 in renal blood vessels
1) Confidence 0.50 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092662 Disease Relevance 0.48 Pain Relevance 0.18
For example, 3 adults had neither meningeal symptoms nor CSF pleocytosis, but nevertheless had E4 detected in the CSF or feces.
Gene_expression (detected) of E4 in feces associated with leukocytosis
2) Confidence 0.48 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874345 Disease Relevance 0.93 Pain Relevance 0
Furthermore, E4 was detected in specimens from several patients with fever and vomiting but with no clinical diagnosis of meningitis.
Gene_expression (detected) of E4 associated with meningitis, vomiting and fever
3) Confidence 0.48 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874345 Disease Relevance 1.46 Pain Relevance 0
While this evidence appears in contrast to the strong association of E4 with risk of Alzheimer's disease (Corder et al., 1993) and to published work on the possible impact of APOE polymorphisms in sCJD showing an overrepresentation of the E4 allele in sCJD patients (Amouyel et al., 1994; Van Everbroeck et al., 2001), such findings have not been replicated in all published studies (Nakagawa et al., 1995; Zerr et al., 1996) nor in our own observations (387 sCJD patients versus unaffected controls, unpublished data).
Gene_expression (allele) of E4 associated with disease
4) Confidence 0.46 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.43 Pain Relevance 0
From VP1 sequences the E4 strain was most closely related to a Japanese E4 strain and 2 Chinese E4 strains.
Gene_expression (strain) of E4 associated with sprains and strains
5) Confidence 0.36 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874345 Disease Relevance 1.11 Pain Relevance 0
In the remaining 19, E4 was detected by PCR from a throat swab, a fecal specimen, or both.
Gene_expression (detected) of E4
6) Confidence 0.32 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874345 Disease Relevance 0.05 Pain Relevance 0
The 293-ORF6 cell line used to propagate these vectors was developed by stably transforming HEK293 cells (of human embryonic kidney origin) with an inducible E4-ORF6 expression cassette, enabling the cells to efficiently complement the E1-, E4-, and partial E3-deleted adenoviral vector [15], [16].
Gene_expression (expression) of E4 in embryonic kidney
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965084 Disease Relevance 0.20 Pain Relevance 0

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