INT348626

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 5
Disease Relevance 4.65
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vasp) cytoskeleton (Vasp) cytoplasm (Vasp)
Anatomy Link Frequency
Blood 2
neuronal 1
brain 1
Vasp (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 40 86.08 High High
Inflammation 10 5.00 Very Low Very Low Very Low
isoflurane 10 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 40 99.08 Very High Very High Very High
Pressure And Volume Under Development 140 98.48 Very High Very High Very High
Adhesions 30 97.56 Very High Very High Very High
Stroke 105 97.40 Very High Very High Very High
Brain Hemorrhage 30 87.28 High High
Middle Cerebral Artery Infarction 10 79.60 Quite High
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Neurological Disease 10 5.00 Very Low Very Low Very Low
Infarction 5 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypoxia has been shown to foster vascular leakage by downregulation of VASP in vitro but the significance of VASP for regulating vascular permeability in the hypoxic brain in vivo awaits clarification.


Negative_regulation (downregulation) of VASP in brain associated with hypoxia
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997079 Disease Relevance 1.07 Pain Relevance 0.04
mice [18] and hypoxia has been shown to foster vascular leakage by downregulation of VASP in vitro [28].
Negative_regulation (downregulation) of VASP associated with hypoxia
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997079 Disease Relevance 0.65 Pain Relevance 0
Vasp deficiency resulted in enhanced BBB disruption, edema formation and neuronal damage after experimental stroke in mice.
Negative_regulation (deficiency) of Vasp in neuronal associated with pressure and volume under development and stroke
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997079 Disease Relevance 0.74 Pain Relevance 0
Deficiency of Vasodilator-Stimulated Phosphoprotein (VASP) Increases Blood-Brain-Barrier Damage and Edema Formation after Ischemic Stroke in Mice

Background

Negative_regulation (Deficiency) of VASP in Blood associated with pressure and volume under development and stroke
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2997079 Disease Relevance 1.10 Pain Relevance 0.03
Deficiency of Vasodilator-Stimulated Phosphoprotein (VASP) Increases Blood-Brain-Barrier Damage and Edema Formation after Ischemic Stroke in Mice

Background

Negative_regulation (Deficiency) of Vasodilator-Stimulated Phosphoprotein in Blood associated with pressure and volume under development and stroke
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2997079 Disease Relevance 1.09 Pain Relevance 0.03

General Comments

This test has worked.

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