INT34870

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 10.66
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1) mitochondrion organization (OPA1) GTPase activity (OPA1)
Anatomy Link Frequency
coronary artery 1
plasma 1
Internal jugular 1
heart 1
upper arm 1
OPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
central sensitization 3 99.98 Very High Very High Very High
Angina 7 99.50 Very High Very High Very High
Glutamate 5 99.34 Very High Very High Very High
tolerance 6 99.12 Very High Very High Very High
Perioperative pain 6 98.98 Very High Very High Very High
nMDA receptor antagonist 2 98.12 Very High Very High Very High
Analgesic 14 97.36 Very High Very High Very High
Lasting pain 2 95.60 Very High Very High Very High
Pain 41 94.28 High High
anesthesia 18 93.84 High High
Disease Link Frequency Relevance Heat
Low Tension Glaucoma 101 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 59 100.00 Very High Very High Very High
Glaucoma 80 99.98 Very High Very High Very High
Pathologic Constriction 2 99.98 Very High Very High Very High
Ocular Hypertension 59 99.84 Very High Very High Very High
Cv General 3 Under Development 19 99.50 Very High Very High Very High
Optic Disorders 6 99.24 Very High Very High Very High
Pain 42 98.98 Very High Very High Very High
Disease 41 98.12 Very High Very High Very High
Pressure Volume 2 Under Development 12 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to determine whether or not plasma glutamate levels are also elevated in NTG.
Spec (whether) Positive_regulation (elevated) of NTG in plasma associated with glutamate and glaucoma
1) Confidence 0.59 Published 2010 Journal Ophthalmic Res. Section Abstract Doc Link 20068372 Disease Relevance 0.64 Pain Relevance 0.40
OPA1 mutations in DOA+
Positive_regulation (mutations) of OPA1
2) Confidence 0.50 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0 Pain Relevance 0
In contrast, exercise tolerance to onset of angina showed a marked initial increase on intravenous NTG but fell progressively and did not differ from that with placebo at 24 hr.
Positive_regulation (increase) of NTG associated with angina and tolerance
3) Confidence 0.40 Published 1988 Journal Circulation Section Abstract Doc Link 3131041 Disease Relevance 0.24 Pain Relevance 0.29
Coronary CMR detected a significant increase in coronary CSA with NTG in both patients and controls (p < 0.0001 for both), but the degree of coronary artery vasodilation to NTG was significant impaired in patients compared to controls (17.8 ± 7.3% vs. 25.6 ± 7.1%, p = 0.002, Figures 1, 2, 3).
Positive_regulation (increase) of NTG in coronary artery associated with increased venous pressure under development
4) Confidence 0.35 Published 2008 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2467421 Disease Relevance 0.82 Pain Relevance 0
All drug treatments lowered IOP in OHT subjects, but did not change OPA significantly.
Neg (not) Positive_regulation (change) of OPA associated with ocular hypertension
5) Confidence 0.34 Published 1994 Journal Surv Ophthalmol Section Abstract Doc Link 7940142 Disease Relevance 1.87 Pain Relevance 0.09
There was a significant amplitude increase in the 5th VEP block (p=0.03) at 1h after NTG and in the 1st block (p=0.04) at 4 h.
Positive_regulation (increase) of NTG
6) Confidence 0.32 Published 2009 Journal Pain Section Abstract Doc Link 19457613 Disease Relevance 0.52 Pain Relevance 0.42
In the NTG group, increases in IOP after succinylcholine and after tracheal intubation were significantly less than in the control (saline) group.
Positive_regulation (increases) of NTG associated with ocular hypertension
7) Confidence 0.30 Published 1988 Journal Anesth. Analg. Section Abstract Doc Link 3132868 Disease Relevance 0.58 Pain Relevance 0.15
Therefore, NMDA receptor antagonists have been implicated in perioperative pain management as they modulate central sensitization induced both by the incision and tissue damage.[6] Nitroglycerin (NTG), a nitric oxide generator, has been demonstrated to enhance the analgesic action of many drugs in acute and chronic pain conditions.
Positive_regulation (induced) of NTG associated with pain, nmda receptor antagonist, central sensitization, lasting pain, analgesic and perioperative pain
8) Confidence 0.25 Published 2010 Journal Saudi Journal of Anaesthesia Section Body Doc Link PMC2945515 Disease Relevance 0.77 Pain Relevance 2.21
Intrapulmonary shunting decreased with induction and, in the NTG and SNP groups, increased slightly but not significantly with induction of hypotension.
Neg (not) Positive_regulation (increased) of NTG associated with pressure volume 2 under development
9) Confidence 0.16 Published 1986 Journal Neurosurgery Section Abstract Doc Link 3093914 Disease Relevance 0.32 Pain Relevance 0.62
It has been reported that blunted BP and heart rate modulation were frequently observed in NTG subjects.33 Yazici et al.34 found that excessive and repetitive nocturnal BP drops occur more frequently in some patients with NTG compared to patients with high-tension glaucoma (HTG) and ocular hypertension (OHT).
Positive_regulation (observed) of NTG in heart associated with low tension glaucoma, glaucoma and ocular hypertension
10) Confidence 0.12 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2655738 Disease Relevance 1.11 Pain Relevance 0.08
Recently, a high percentage of NTG patients were found to exhibit an Alzheimer's disease (AD)-like cerebral perfusion pattern, although none were clinically diagnosed with AD.
Positive_regulation (percentage) of NTG associated with low tension glaucoma and disease
11) Confidence 0.12 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2655738 Disease Relevance 1.27 Pain Relevance 0
During placebo, ischemia frequency decreased 58% (patch-on to patch-off, p = 0.01) compared with a 14% increase with TD-NTG.
Positive_regulation (increase) of TD-NTG
12) Confidence 0.09 Published 1997 Journal J. Am. Coll. Cardiol. Section Body Doc Link 9316524 Disease Relevance 0 Pain Relevance 0
We considered using the NTG patch instead of NTG ointment.
Positive_regulation (using) of NTG
13) Confidence 0.08 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.08 Pain Relevance 0.14
Compared with baseline, treatment with NTG increased BMD in ovariectomized rats (20% ± 3%) to levels similar to those found in sham operated rats (25% ± 2%) and the increase in BMD in ovariectomized rats treated with NTG ointment (20% ± 3%) was greater than the increase in ovariectomized rats treated with vehicle (8% ± 3%) (Table 1).
Positive_regulation (increased) of NTG
14) Confidence 0.08 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.37 Pain Relevance 0
Subjects will receive NTG ointment; at 15 mg/day (one inch of 2% ointment applied to the upper arm) for one week and ISMO at 20 mg/day for one week.
Positive_regulation (receive) of NTG in upper arm
15) Confidence 0.08 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.20 Pain Relevance 0.20
Therefore, NTG was always administered first, and followed by salbutamol 25 minutes later.


Positive_regulation (followed) of NTG
16) Confidence 0.04 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815836 Disease Relevance 0.18 Pain Relevance 0.05
Individuals carrying the 163 allele of D7S1277i had a statistically significant increased risk of NTG (p=0.0013, pc=0.016, OR=2.47, 95%CI=1.42–4.30).
Positive_regulation (increased) of NTG associated with low tension glaucoma
17) Confidence 0.03 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2842094 Disease Relevance 0.42 Pain Relevance 0
Coronary luminal stenosis increased from 48 +/- 29% to 67 +/- 25% after NTG (p < 0.001) and to 83 +/- 18% (p < 0.001) after ORC.
Positive_regulation (increased) of NTG associated with pathologic constriction
18) Confidence 0.03 Published 1994 Journal Z Kardiol Section Abstract Doc Link 7825370 Disease Relevance 1.11 Pain Relevance 0.24
Internal jugular venous pressure increased significantly during NTG but not during PGE1 infusion (P < 0.05).
Neg (not) Positive_regulation (increased) of NTG in Internal jugular associated with increased venous pressure under development
19) Confidence 0.01 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9356099 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

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