INT348723

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.30 Pain Relevance 0

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

ED (Mus musculus) PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat Bioavailability 3 5.00 antagonist 3 5.00 ischemia 3 5.00 Clonidine 2 5.00 antidepressant 2 5.00 Calcium channel 2 5.00 depression 2 5.00 Angina 2 5.00 Central nervous system 1 5.00 Spinal cord 1 5.00

Disease Link Frequency Relevance Heat Erectile Dysfunction 74 100.00 Diabetes Mellitus 28 99.76 Apoptosis 1 98.64 Increased Venous Pressure Under Development 14 96.80 Cardiovascular Disease 12 67.52 Hypertension 18 5.00 Disease 10 5.00 Reprotox - General 2 7 5.00 Sickle Cell Anemia 3 5.00 Hyperlipidemia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A more recent study suggested that diabetic-associated ED due to upregulation of the penile RhoA/Rho-kinase pathway enhances PTEN/Akt activity leading to corporal apoptosis [91].

ED Positive_regulation (enhances) of PTEN associated with erectile dysfunction, diabetes mellitus and apoptosis

1) Confidence 0.04 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 1.30 Pain Relevance 0

General Comments

This test has worked.