INT348784

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.47
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ins1, Irs1) carbohydrate metabolic process (Ins1) signal transducer activity (Irs1)
cytosol (Irs1) extracellular space (Ins1) extracellular region (Ins1)
Anatomy Link Frequency
liver 1
muscle 1
adipose tissue 1
Ins1 (Rattus norvegicus)
Irs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 18 96.84 Very High Very High Very High
cytokine 39 67.72 Quite High
Inflammation 99 67.32 Quite High
Inflammatory response 12 23.00 Low Low
Inflammatory mediators 12 20.52 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 60 99.30 Very High Very High Very High
Obesity 60 96.36 Very High Very High Very High
Sepsis 189 90.44 High High
Apoptosis 9 87.52 High High
Adhesions 3 83.32 Quite High
INFLAMMATION 123 67.32 Quite High
Death 9 26.08 Quite Low
Multiple Organ Failure 6 25.68 Quite Low
Stress 39 5.00 Very Low Very Low Very Low
Hyperglycemia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
insulin Positive_regulation (induced) of IRS-1 in adipose tissue associated with obesity and insulin resistance
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.16 Pain Relevance 0.15
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
insulin Positive_regulation (induced) of IRS-1 in liver associated with obesity and insulin resistance
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.16 Pain Relevance 0.15
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
insulin Positive_regulation (induced) of IRS-1 in muscle associated with obesity and insulin resistance
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.16 Pain Relevance 0.15

General Comments

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