INT348786

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Mapk8) cytoplasm (Tlr4, Mapk8) cytosol (Mapk8)
mitochondrion (Mapk8) nucleus (Mapk8) plasma membrane (Tlr4)
Tlr4 (Rattus norvegicus)
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 33 96.76 Very High Very High Very High
Inflammatory response 4 64.40 Quite High
cytokine 13 7.48 Low Low
tolerance 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 20 98.00 Very High Very High Very High
Infection 4 97.20 Very High Very High Very High
INFLAMMATION 41 96.76 Very High Very High Very High
Obesity 20 96.20 Very High Very High Very High
Hyperlipidemia 1 95.72 Very High Very High Very High
Stress 13 93.96 High High
Sepsis 63 84.00 Quite High
Endotoxemia 2 45.52 Quite Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides being activated by TLR4, JNK activity is induced in different pathophysiological states including infection, inflammation, obesity and hyperlipidemia, also as a consequence of ER stress [66], [67], [68].
TLR4 Positive_regulation (activated) of JNK associated with stress, inflammation, obesity, hyperlipidemia and infection
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.09 Pain Relevance 0.11

General Comments

This test has worked.

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