INT34891

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Context Info
Confidence 0.72
First Reported 1986
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.69
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
lactotroph 3
plasma 2
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 13 99.60 Very High Very High Very High
Endogenous opioid 11 96.32 Very High Very High Very High
Dopamine 252 96.00 Very High Very High Very High
gABA 52 91.28 High High
Somatostatin 8 90.80 High High
Kinase C 4 90.80 High High
Serotonin 128 87.28 High High
Clonidine 6 87.20 High High
Neuropeptide 8 84.24 Quite High
opioid receptor 1 81.00 Quite High
Disease Link Frequency Relevance Heat
Vomiting 17 96.52 Very High Very High Very High
Hypertension 24 88.96 High High
Reprotox - General 1 116 77.48 Quite High
Gynecomastia 28 76.32 Quite High
Galactorrhea 533 75.76 Quite High
Post-traumatic Stress Disorder 1 75.00 Quite High
Disease 12 71.16 Quite High
Alcohol Addiction 1 47.64 Quite Low
Osteoporosis 5 47.16 Quite Low
Nicotine Addiction 1 45.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogens modulate prolactin secretion in response to reproductive events through different mechanisms: amplification of mitotic activity of the lactotrophs, enhancement of prolactin gene transcription and translation through ER?
Transcription (transcription) of prolactin in lactotrophs
1) Confidence 0.72 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.40
The dopamine-mediated inhibition of prolactin secretion occurs through the binding of D2 receptors on the membrane of lactotroph cells and involves several signal transduction systems, resulting in inhibition of prolactin gene transcription, reduction of prolactin synthesis and release.
Transcription (transcription) of prolactin in lactotroph associated with dopamine
2) Confidence 0.72 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.30
VIP (and a fragment of its precursor named peptide his-isoleucine) acts both via hypothalamic afferents and direct paracrine and autocrine mechanisms, through lactotroph cell receptors binding, enhancing adenylate cyclase activity and increasing prolactin gene transcription.
Transcription (transcription) of prolactin in lactotroph
3) Confidence 0.69 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.51
To achieve prolactin levels in the range of those measured in postpartum women, i.e. 100–250 ?
Transcription (achieve) of prolactin
4) Confidence 0.65 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.07 Pain Relevance 0
Effects of naloxone infusion on plasma levels of LH, FSH, and in addition TSH and prolactin in males, before and after oestrogen or anti-oestrogen treatment.
Transcription (levels) of prolactin in plasma associated with narcan
5) Confidence 0.64 Published 1986 Journal Horm. Metab. Res. Section Title Doc Link 3096859 Disease Relevance 0 Pain Relevance 0.56
The effect on prolactin levels of the classical antypsichotic chlorpromazine, used in clinical practice for its anti-nausea properties, has been discussed above.


Transcription (levels) of prolactin associated with vomiting
6) Confidence 0.53 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.55 Pain Relevance 0.12
Level of alertness, autonomic functions (pupil diameter, blood pressure, heart rate, salivation, temperature) and the plasma levels of the hormones prolactin, thyroid-stimulating hormone and growth hormone were also measured.
Transcription (levels) of prolactin in plasma
7) Confidence 0.29 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17342169 Disease Relevance 0.07 Pain Relevance 0.48

General Comments

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