INT348938

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (TRMT2A)
Anatomy Link Frequency
urine 3
TRMT2A (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 3 53.88 Quite High
Chronic pancreatitis 3 52.76 Quite High
Disease Link Frequency Relevance Heat
Ovarian Cancer 87 97.92 Very High Very High Very High
Disease 9 82.64 Quite High
Cancer 57 75.68 Quite High
Renal Disease 3 54.88 Quite High
Interstitial Cystitis 3 53.88 Quite High
Pancreatitis 3 52.76 Quite High
Cervical Cancer 3 27.28 Quite Low
Breast Cancer 3 25.36 Quite Low
Gastrointestinal Neoplasms 3 24.56 Low Low
Bladder Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The different altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma, relative to the controls, was confirmed when their 2-DE urine protein profiles were subjected to image analysis using the Image Master 2 D Platinum Software 7.0.
Gene_expression (levels) of fragments in urine associated with ovarian cancer
1) Confidence 0.01 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.23 Pain Relevance 0
Further confirmation of the altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma relative to those of the control subjects was performed using antibodies and a lectin that bind to the respective proteins that were blotted onto membranes.
Gene_expression (levels) of fragments in urine associated with ovarian cancer
2) Confidence 0.01 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.47 Pain Relevance 0
This inverse relationship and the difference in the molecular masses of the ITIH4 fragments detected in the respective samples suggest presence of a selective glomerular filtration mechanism that retained the 35 kDa fragment in the blood but allowed its 39 kDa counterpart to be excreted in the urine.
Gene_expression (detected) of fragments in urine
3) Confidence 0.01 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.69 Pain Relevance 0.11

General Comments

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