INT34904

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Context Info
Confidence 0.15
First Reported 1986
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 38.88
Pain Relevance 13.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
neuron 3
myeloid cell 2
synovial fluid 1
MDM 1
dentate gyrus 1
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 526 100.00 Very High Very High Very High
cytokine 363 100.00 Very High Very High Very High
antagonist 73 100.00 Very High Very High Very High
metalloproteinase 28 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
Nerve growth factor 4 100.00 Very High Very High Very High
rheumatoid arthritis 476 99.92 Very High Very High Very High
Cancer pain 24 99.90 Very High Very High Very High
cINOD 132 99.84 Very High Very High Very High
Osteoarthritis 110 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 633 100.00 Very High Very High Very High
INFLAMMATION 499 100.00 Very High Very High Very High
Necrosis 61 100.00 Very High Very High Very High
Repression 12 100.00 Very High Very High Very High
Spinal Tumor 1 100.00 Very High Very High Very High
Hypoxia 61 99.98 Very High Very High Very High
Rheumatoid Arthritis 477 99.92 Very High Very High Very High
Targeted Disruption 140 99.88 Very High Very High Very High
Bone Cancer 34 99.80 Very High Very High Very High
Rheumatic Diseases 5 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A platelet activating factor antagonist and a matrix metalloproteinase inhibitor, which also inhibits tumor necrosis factor alpha release, were administered to animals at the time of the MDM inoculation.
Negative_regulation (inhibitor) of factor in MDM associated with necrosis, cancer, antagonist and metalloproteinase
1) Confidence 0.15 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240016 Disease Relevance 1.06 Pain Relevance 0.31
We previously postulated that these regressive changes in the OPC/CFU-f compartment occurred in old animals because of a reduction in the amount and/or activity of TGF-beta1, an autocrine growth factor important in the promotion of OPC/CFU-f proliferation and differentiation.
Negative_regulation (reduction) of factor
2) Confidence 0.12 Published 1998 Journal J. Cell. Biochem. Section Abstract Doc Link 9712146 Disease Relevance 0.77 Pain Relevance 0.07
Behavioral alterations are associated with a decrease in brain-derived neurotrophic factor (BDNF) mRNA in the hippocampal dentate gyrus and fluoxetine treatment restores BDNF mRNA expression.
Negative_regulation (decrease) of factor in dentate gyrus associated with fluoxetine
3) Confidence 0.08 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18485098 Disease Relevance 0.24 Pain Relevance 0.43
We examined whether, heparin binding-epidermal growth factor-like growth factor (HB-EGF), a recently described member of the epidermal growth factor (EGF) family, might compete with an inhibitory opioid signal.
Spec (might) Negative_regulation (compete) of factor associated with opioid
4) Confidence 0.08 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729296 Disease Relevance 0.15 Pain Relevance 1.06
These data indicate that over-expressed PACAP in pancreas enhances the cerulein-induced inflammatory response of both acinar cells, leading to aggravated acute pancreatitis, which was accompanied by a down-regulation of RegIIIbeta, an anti-inflammatory factor.
Negative_regulation (down-regulation) of factor in pancreas associated with inflammatory response, inflammation and pancreatitis
5) Confidence 0.07 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.92 Pain Relevance 0.20
DRG11, a paired homeodomain transcription factor, is expressed in both the developing dorsal horn and in sensory neurons, but not in the ventral spinal cord.
Negative_regulation (paired) of factor in ventral associated with dorsal horn and spinal cord
6) Confidence 0.06 Published 2001 Journal Neuron Section Abstract Doc Link 11498051 Disease Relevance 0.16 Pain Relevance 0.31
First, diclofenac yields a significant antiangiogenic effect, as demonstrated by a strong reduction in vascular endothelial growth factor (VEGF) tumor content, decreased microvascular density and morphological changes in tumor blood vessels.
Negative_regulation (reduction) of factor in blood vessels associated with cancer and diclofenac
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 1.01 Pain Relevance 0.38
Several reagents against the TF complex at sequential steps in its assembly, including a competitive inhibitor of Factor VIIa and an antibody to the Factor X binding site on TF, were tested in an E. coli sepsis model in baboons [4], [14], [15].
Negative_regulation (inhibitor) of Factor associated with sepsis
8) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.54 Pain Relevance 0.26
Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-?
Negative_regulation (decreases) of factor in spinal associated with necrosis, cancer pain, spinal tumor and bone cancer
9) Confidence 0.03 Published 2010 Journal Mol Pain Section Title Doc Link PMC2959022 Disease Relevance 1.73 Pain Relevance 0.92
Incubation with the extract was associated with a concentration-dependent reduction of interferon beta and interferon regulatory factor 1 mRNA.
Negative_regulation (reduction) of factor
10) Confidence 0.03 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
Runx1 expression in these cells is first observed at approximately gestational day 12.5, persists into the adult brain, and is lost in knockout mice lacking the transcription factor Atoh1, an important regulator of the development of neuronal lineages of the rhombic lip.
Negative_regulation (lacking) of factor in neuronal associated with targeted disruption
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978708 Disease Relevance 0.10 Pain Relevance 0.19
ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear factor ?
Negative_regulation (inhibit) of factor
12) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526548 Disease Relevance 0.71 Pain Relevance 0.50
Molecular mechanisms associated with these events include a reduction in the activity of the transcription factor NF?
Negative_regulation (reduction) of factor
13) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.55 Pain Relevance 0.34
Recently, prevention of leukocyte infiltration in inflamed tissue by blocking chemokines or chemokine receptors has also been explored but with limited success [6], possibly due to redundancy, enabling efficient leukocyte responses, even when one particular factor is blocked.
Negative_regulation (blocked) of factor in leukocyte associated with chemokine
14) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.41 Pain Relevance 0.45
Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer

Bevacizumab is a monoclonal antibody that inhibits vascular endothelial growth factor (VEGF).

Negative_regulation (inhibits) of factor associated with takotsubo cardiomyopathy and metastasis
15) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Title Doc Link PMC2643117 Disease Relevance 1.15 Pain Relevance 0.09
Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor.
Negative_regulation (down-regulation) of factor in neck associated with skin cancer and opioid
16) Confidence 0.01 Published 2006 Journal Int. J. Oncol. Section Title Doc Link 16685459 Disease Relevance 0.82 Pain Relevance 0.39
Of note, we have not been able to detect a direct effect of rhBCL2 or rhBCL2A1 on apoptosis in vitro in HEK TLR2 transfectants challenged with etoposide or in a myeloid cell line subjected to growth factor deprivation (Figs.
Negative_regulation (deprivation) of factor in myeloid cell associated with apoptosis
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.96 Pain Relevance 0.07
Results in HEK TLR2/6 transfectants challenged with etoposide or the 32D myeloid cell line subjected to growth factor deprivation are shown in Figures S5 and S6, respectively.


Negative_regulation (deprivation) of factor in myeloid cell
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.57 Pain Relevance 0
It exerts potent anti-inflammatory and antioxidative effects, by suppression of tumor necrosis factor-?
Negative_regulation (suppression) of factor associated with necrosis, inflammation and cancer
19) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785861 Disease Relevance 1.30 Pain Relevance 0.20
Inhibition of IL-2 activation by PB was demonstrated to result from a blockade of the mitogenic growth factor signal using the IL-2-dependent cell line HT-2.
Negative_regulation (blockade) of factor
20) Confidence 0.01 Published 1986 Journal Transplantation Section Abstract Doc Link 3097893 Disease Relevance 0 Pain Relevance 0.21

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