INT34905

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Context Info
Confidence 0.50
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 7.46
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
chondrocytes 4
endothelium 4
neurons 2
neutrophils 2
body 2
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 596 99.52 Very High Very High Very High
antagonist 20 98.08 Very High Very High Very High
Inflammatory response 18 94.32 High High
Inflammation 135 93.08 High High
COX-2 inhibitor 23 92.64 High High
cINOD 44 91.40 High High
tetrodotoxin 1 83.40 Quite High
Potency 4 78.72 Quite High
Inflammatory mediators 4 70.72 Quite High
Arthritis 8 63.52 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 616 99.52 Very High Very High Very High
Aging 5 99.32 Very High Very High Very High
Hypertension 92 98.36 Very High Very High Very High
Hypotension 4 97.24 Very High Very High Very High
Calcification 24 97.08 Very High Very High Very High
Breast Cancer 37 96.96 Very High Very High Very High
INFLAMMATION 170 94.32 High High
Stroke 6 92.60 High High
Increased Venous Pressure Under Development 28 92.16 High High
Disease 37 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In PLT, orpanoxin (100 mumols/l) inhibited formation of cyclo-oxygenase products (thromboxanes, prostaglandins, and 12-L-hydroxy-5,8,10-heptadecatrienoic acid) and increased synthesis of the lipoxygenase product, 12S-hydroxy-5,8-cis,10-trans,14-cis-eicosatetraenoic acid.
Positive_regulation (increased) of Gene_expression (synthesis) of lipoxygenase
1) Confidence 0.50 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3152163 Disease Relevance 0.08 Pain Relevance 0.18
Four lipoxygenase pathway variants contributed to variation in CorCP—one in ALOX5 (rs2115819), one in ALOX12 (rs2271316), and two in ALOX5AP (rs9506352 and rs4769060).
Positive_regulation (variation) of Gene_expression (one) of ALOX5
2) Confidence 0.47 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.43 Pain Relevance 0
Four lipoxygenase pathway variants contributed to variation in CorCP—one in ALOX5 (rs2115819), one in ALOX12 (rs2271316), and two in ALOX5AP (rs9506352 and rs4769060).
Positive_regulation (variation) of Gene_expression (two) of ALOX5
3) Confidence 0.47 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.43 Pain Relevance 0
This suggested a predominant role for arachidonate lipoxygenase products.
Positive_regulation (role) of Gene_expression (products) of lipoxygenase
4) Confidence 0.42 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3098393 Disease Relevance 0.07 Pain Relevance 0.08
We recently reported that aging is associated with a significant increase in neuronal 5-LOX gene expression and with increased, 5-LOX inhibitor-sensitive, vulnerability of neurons to degeneration.
Positive_regulation (increase) of Gene_expression (expression) of neuronal 5-LOX in neurons associated with aging
5) Confidence 0.40 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790729 Disease Relevance 0.85 Pain Relevance 0.18
Indeed, increases in lipid body numbers correlated with enhanced production of both lipoxygenase- and cyclooxygenase-derived eicosanoids.
Positive_regulation (enhanced) of Gene_expression (production) of lipoxygenase in body
6) Confidence 0.24 Published 1997 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 9698925 Disease Relevance 0.15 Pain Relevance 0.18
In contrast, naproxen induced 5-LOX expression after short or long stimulation time periods.
Positive_regulation (induced) of Gene_expression (expression) of 5-LOX
7) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.41 Pain Relevance 0.23
1 production could be involved in HNE-induced 5-LOX and FLAP expression, chondrocytes were treated or not with a single addition of 10 ?
Positive_regulation (involved) of Gene_expression (expression) of 5-LOX in chondrocytes
8) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
To more accurately identify whether HNE induced 5-LOX at the transcription level, the 5-LOX promoter construct with luciferase gene reporter was transiently transfected into human OA chondrocytes, followed by stimulation with single addition of 10 ?
Positive_regulation (transfected) of Gene_expression (transfected) of 5-LOX in chondrocytes associated with osteoarthritis
9) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.27 Pain Relevance 0.13
These results are consistent with a previous report of Martel-Pelletier and colleagues showing that 5-LOX expression is activated after that of FLAP, leading to the late increase of LTB4 production [28].
Positive_regulation (activated) of Gene_expression (expression) of 5-LOX
10) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.14 Pain Relevance 0.07
In macrophages, the shunt from the COX to the 5-LO pathway is due to an increase in 5-LO expression [28,29], whereas in alveolar macrophages and in neutrophils it is due to altered 5-lipoxygenase-activating protein (FLAP) expression [30,31].
Positive_regulation (increase) of Gene_expression (expression) of 5-LO in neutrophils
11) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.39 Pain Relevance 0.24
This shunt was either related to an increase in 5-LO expression or that of FLAP through an IL-10-dependent or IL-18-dependent pathway in other cell systems.
Positive_regulation (increase) of Gene_expression (expression) of 5-LO
12) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.61 Pain Relevance 0.36
enhanced the expression of 5-LO [28,29,45,46] or both 5-LO and FLAP [44].
Positive_regulation (enhanced) of Gene_expression (expression) of 5-LO
13) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.58 Pain Relevance 0.26
expended by the pharmaceutical industry to produce inhibitors of FLAP, 5-LOX as
Positive_regulation (expended) of Gene_expression (produce) of 5-LOX
14) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.54 Pain Relevance 0.17
The production of LTs requires active 5-LO in the presence of calcium [25,26], yet arachidonic acid must be presented by the 5-LO-activating protein [25,27].
Positive_regulation (requires) of Gene_expression (presented) of 5-LO
15) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.43 Pain Relevance 0.26
The conclusion that ACSL4 may regulate COX-2 expression through the activation of lipoxygenase products is in line with previous observations showing that leukotriene B4, a product of 5-HETE, positively regulates the levels and stability of COX-2 mRNA and protein expression in synovial living cells [33].
Positive_regulation (activation) of Gene_expression (products) of lipoxygenase
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.32 Pain Relevance 0
Considering the blood pressure lowering effects and cerebrovascular protective effects of LO inhibitors on one hand, and the beneficial effects on arterial blood pressure of 15-LO overexpression on the other hand, it is difficult to decide on the potential benefit of stimulating the production of LO-derived endothelium-derived relaxing factors in hypertension.
Positive_regulation (stimulating) of Gene_expression (production) of LO-derived in endothelium associated with hypertension and hypotension
17) Confidence 0.04 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.89 Pain Relevance 0.05
Considering the blood pressure lowering effects and cerebrovascular protective effects of LO inhibitors on one hand, and the beneficial effects on arterial blood pressure of 15-LO overexpression on the other hand, it is difficult to decide on the potential benefit of stimulating the production of LO-derived endothelium-derived relaxing factors in hypertension.
Positive_regulation (overexpression) of Gene_expression (overexpression) of LO in endothelium associated with hypertension and hypotension
18) Confidence 0.04 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.83 Pain Relevance 0.04

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