INT349050

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF845) intracellular (ZNF845) plasma membrane (EPCAM)
DNA binding (ZNF845)
EPCAM (Homo sapiens)
ZNF845 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Dysuria 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 10 100.00 Very High Very High Very High
Apoptosis 2 96.84 Very High Very High Very High
Cancer 42 92.24 High High
Lower Urinary Tract Symptoms 2 89.64 High High
Bladder Cancer 20 89.20 High High
Toxicity 30 88.64 High High
Transitional Cell Carcinoma 14 80.88 Quite High
Disease 16 77.48 Quite High
Adhesions 2 76.04 Quite High
Recurrence 12 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It consists of an anti-EpCAM humanized single-chain variable fragment (scFv) linked to a truncated form of Pseudomonas exotoxin A (ETA252–608) that lacks the cell-binding domain.12 Once bound to EpCAM on the surface of carcinoma cells, VB4-845 is internalized, whereupon the exotoxin portion of the fusion protein induces apoptosis.13,14
EpCAM Binding (bound) of VB4-845 associated with carcinoma and apoptosis
1) Confidence 0.02 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998804 Disease Relevance 1.21 Pain Relevance 0
VB4-845 is a targeted therapy that exerts its effect via specific interaction with the cell surface antigen EpCAM.
EpCAM Binding (interaction) of VB4-845
2) Confidence 0.02 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998804 Disease Relevance 0.33 Pain Relevance 0

General Comments

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