INT349051

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPCAM)
EPCAM (Homo sapiens)
SCFV (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Dysuria 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 5 99.24 Very High Very High Very High
Cancer 21 96.84 Very High Very High Very High
Apoptosis 1 95.12 Very High Very High Very High
Bladder Cancer 10 93.80 High High
Transitional Cell Carcinoma 7 85.48 High High
Toxicity 15 85.20 High High
Adhesions 1 80.64 Quite High
Recurrence 6 74.96 Quite High
Disease 8 65.24 Quite High
Glioblastoma 1 44.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It consists of an anti-EpCAM humanized single-chain variable fragment (scFv) linked to a truncated form of Pseudomonas exotoxin A (ETA252–608) that lacks the cell-binding domain.12 Once bound to EpCAM on the surface of carcinoma cells, VB4-845 is internalized, whereupon the exotoxin portion of the fusion protein induces apoptosis.13,14
EpCAM Binding (bound) of scFv associated with carcinoma and apoptosis
1) Confidence 0.03 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998804 Disease Relevance 1.37 Pain Relevance 0

General Comments

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