INT349104

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hyal1) cell death (Hyal1) extracellular region (Hyal1)
carbohydrate metabolic process (Hyal1) lysosome (Hyal1) cytoplasm (Hyal1)
Anatomy Link Frequency
plasma 3
Hyal1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 92.60 High High
Inflammatory response 3 24.24 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Proteinuria 15 99.96 Very High Very High Very High
INFLAMMATION 15 92.60 High High
Atherosclerosis 39 88.56 High High
Hyperlipoproteinemia Type Ii 3 84.24 Quite High
Disorder Of Lipid Metabolism 9 80.88 Quite High
Rupture 6 76.28 Quite High
Albuminuria 3 73.64 Quite High
Atherosclerotic Plaque 6 73.60 Quite High
Pressure And Volume Under Development 3 55.44 Quite High
Disease 3 34.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in animals and patients with DM1, both characterized by increased risk for development of proteinuria, plasma hyaluronidase levels are elevated and associated with decreased endothelial surface layer, underscoring potential clinical relevance [25], [29].


Positive_regulation (elevated) of plasma hyaluronidase in plasma associated with proteinuria
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999536 Disease Relevance 0.44 Pain Relevance 0
Second, we found increased IL-6 plasma levels upon both activated and inactivated hyaluronidase infusion.
Positive_regulation (inactivated) of hyaluronidase in plasma
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999536 Disease Relevance 0.32 Pain Relevance 0
Infusion with active hyaluronidase resulted in decreased ESL (0.32±0.22 mL) and plasma volume (1.03±0.18 mL) compared to inactivated hyaluronidase (0.52±0.29 mL and 1.28±0.08 mL, p<0.05 respectively).Active hyaluronidase increased proteinuria compared to inactive hyaluronidase (0.27±0.02 vs. 0.15±0.01 µg/µg protein/creatinin, p<0.05) without changes in glomerular morphology or development of tubulo-interstitial inflammation.
Positive_regulation (increased) of hyaluronidase in plasma associated with inflammation and proteinuria
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999536 Disease Relevance 0.51 Pain Relevance 0.05

General Comments

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