INT34912

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Context Info
Confidence 0.08
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.41
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IKBKG) nucleus (IKBKG) cytoplasm (IKBKG)
signal transducer activity (IKBKG)
Anatomy Link Frequency
sciatic nerves 1
IKBKG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 100.00 Very High Very High Very High
chemokine 16 99.26 Very High Very High Very High
Sciatic nerve 2 97.36 Very High Very High Very High
Neuritis 4 94.48 High High
tetrodotoxin 1 93.16 High High
Peripheral nervous system 6 88.60 High High
Calcium channel 1 75.00 Quite High
ischemia 7 71.16 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 100.00 Very High Very High Very High
Disease 5 99.04 Very High Very High Very High
Immunization 2 97.68 Very High Very High Very High
Stress 14 97.44 Very High Very High Very High
Experimental Autoimmune Neuritis 4 95.44 Very High Very High Very High
Infection 26 94.64 High High
Apoptosis 136 88.24 High High
Demyelinating Disease 4 87.08 High High
Pathologic Constriction 11 81.12 Quite High
Cv Unclassified Under Development 10 71.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NEMO is the regulatory subunit of the I?
Regulation (regulatory) of NEMO
1) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.24 Pain Relevance 0
It is noteworthy that IP never increased significantly and to this is associated a steeply increase of its catabolism in peroxisomes as demonstrated by the ratio DIN/IP, suggesting an efficient physiological response to IP formation.
Regulation (response) of IP
2) Confidence 0.06 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.68 Pain Relevance 0.09
The enantiomers of the benzoxadiazol 1,4-dihydropyridine 202-791 showed opposite stereospecific regulation of [3H]IP1 formation: (+)-(S)-202-791 stimulated (252%; ED50: 88 nM), whereas (-)-(R)-202-791 inhibited (65% inhibition, ED50: 602 nM).
Regulation (regulation) of IP1
3) Confidence 0.02 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3098571 Disease Relevance 0 Pain Relevance 0.13
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Regulation (regulated) of IP in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
4) Confidence 0.01 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.74 Pain Relevance 0.60
In contrast, mRNAs for MCP-1, RANTES, and IP-10 exhibited peak levels coincident with peak of the disease at day 15 p.i.
Regulation (mRNAs) of IP associated with disease
5) Confidence 0.01 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.75 Pain Relevance 0.60

General Comments

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