INT349147

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.57
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
cleavage 4
podocytes 2
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 56.56 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 156 90.48 High High
Injury 3 74.88 Quite High
Shock 9 64.48 Quite High
Albuminuria 81 62.72 Quite High
Exsanguination 3 55.56 Quite High
Renal Disease 117 50.28 Quite High
Chronic Renal Failure 3 48.28 Quite Low
Apoptosis 75 5.00 Very Low Very Low Very Low
Stress 30 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of podocytes in high glucose medium for as briefly as 4 hours with a p38MAPK inhibitor attenuated downstream HSP25 phosphorylation, inducing F- to G-actin cleavage, and cytoskeletal disruption.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of HSP25 in cleavage
1) Confidence 0.51 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.31 Pain Relevance 0
Incubation of podocytes in high glucose medium for hours, or incubation with a p38MAPK inhibitor, attenuated downstream HSP25 phosphorylation, inducing F- to G-actin cleavage, and cytoskeletal disruption.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of HSP25 in cleavage
2) Confidence 0.51 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.21 Pain Relevance 0
Cur stimulates phosphorylation of p38MAPK and HSP25 in cultured podocytes
Negative_regulation (podocytes) of Phosphorylation (phosphorylation) of HSP25 in podocytes
3) Confidence 0.37 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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