INT349165

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 4.56
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
podocytes 12
cleavage 4
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 81.28 Quite High
anesthesia 9 57.00 Quite High
COX-2 inhibitor 9 24.16 Low Low
Bioavailability 18 10.52 Low Low
Disease Link Frequency Relevance Heat
Stress 90 98.64 Very High Very High Very High
Heat Stress Disorders 9 97.20 Very High Very High Very High
Diabetes Mellitus 468 92.64 High High
Cancer 9 91.08 High High
Albuminuria 243 90.96 High High
Shock 27 89.72 High High
Apoptosis 225 84.76 Quite High
Glioma 9 84.12 Quite High
Injury 9 83.44 Quite High
INFLAMMATION 27 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of HSP25 in podocytes
1) Confidence 0.61 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.25 Pain Relevance 0
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration (up to 4 hours) resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of HSP25 in podocytes
2) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.51 Pain Relevance 0
Our published work showed that incubating Pods in HG for up to 24 hrs stimulated the phosphorylation of p38MAPK and HSP25 while maintaining the actin cytoskeleton [18].
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of HSP25
3) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
In contrast, in our in vitro studies in curcumin-treated podocytes, phosphorylated HSP25 was increased, but not total HSP25 (not shown).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of HSP25 in podocytes
4) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.06 Pain Relevance 0
In cultured podocytes, curcumin induced the phosphorylation of p38MAPK and downstream HSP25, inhibited COX-2 and the activation of caspase-3, and demonstrated a tendency to attenuate F-actin cleavage to G-actin monomers.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of HSP25 in cleavage
5) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.80 Pain Relevance 0
Cur stimulates phosphorylation of p38MAPK and HSP25 in cultured podocytes
Positive_regulation (stimulates) of Phosphorylation (phosphorylation) of HSP25 in podocytes
6) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.06 Pain Relevance 0.06
In contrast, in our in vitro studies in curcumin-treated podocytes, phosphorylated HSP25 was increased, but not total HSP25 (not shown).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of HSP25 in podocytes
7) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.07 Pain Relevance 0
Incubation of podocytes in high glucose medium for hours, or incubation with a p38MAPK inhibitor, attenuated downstream HSP25 phosphorylation, inducing F- to G-actin cleavage, and cytoskeletal disruption.
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of HSP25 in cleavage
8) Confidence 0.41 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.21 Pain Relevance 0
Our experiments show that in podocytes cultured under basal or high glucose conditions, acute exposure to curcumin induced the phosphorylation of both p38MAPK and downstream HSP25.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of HSP25 in podocytes
9) Confidence 0.38 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.61 Pain Relevance 0.08

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