INT349222

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.40
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A7) extracellular space (CSF2) extracellular region (CSF2)
plasma membrane (SLC7A7) protein complex assembly (SLC7A7) transmembrane transport (SLC7A7)
Anatomy Link Frequency
macrophages 2
monocytes 2
mesenchymal cells 2
CSF2 (Homo sapiens)
SLC7A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 98.16 Very High Very High Very High
Angina 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 105 89.52 High High
Systemic Lupus Erythematosus 3 41.84 Quite Low
Congenital Anomalies 6 39.04 Quite Low
Respiratory Failure 15 5.00 Very Low Very Low Very Low
Pneumothorax 12 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low
Anaemia 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Immunodeficiency 3 5.00 Very Low Very Low Very Low
Interstitial Lung Diseases 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found that: 1) system y+L activity is markedly lowered in monocytes and alveolar macrophages from the LPI patient, because of the prevailing expression of SLC7A7/y+LAT1 in these cells; 2) on the contrary, fibroblasts isolated from the same patient do not display the transport defect due to compensation by the SLC7A6/y+LAT2 isoform; 3) in both normal and LPI monocytes, GM-CSF induces the expression of SLC7A7, suggesting that the gene is a target of the cytokine; 4) GM-CSF-induced differentiation of LPI monocytes is comparable to that of normal cells, demonstrating that GM-CSF signalling is unaltered; 5) general and respiratory conditions of the patient, along with PAP-associated parameters, markedly improved after GM-CSF therapy through aerosolization.


GM-CSF Positive_regulation (induces) of Gene_expression (expression) of SLC7A7 in monocytes associated with pulmonary alveolar proteinosis and cytokine
1) Confidence 0.17 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.31 Pain Relevance 0.05
We have found that: 1) in AM isolated from the WLL fluid of the LPI patient and in peripheral blood monocytes from the same subject system y+L activity is markedly reduced compared to controls; 2) conversely, mesenchymal cells, isolated from the same patient, do not display the transport defect, consistently with our previous results [25]; 3) in both normal and LPI monocytes the expression of SLC7A7 is induced by GM-CSF, suggesting that the transporter gene is a target of the cytokine; 4) GM-CSF induces genes coding for specialized macrophage functions in both normal and LPI monocytes.
GM-CSF Positive_regulation (induced) of Gene_expression (expression) of SLC7A7 in mesenchymal cells associated with cytokine
2) Confidence 0.17 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.08
GM-CSF induces comparable changes in gene expression also in LPI macrophages, where, however, due to the SLC7A7 mutation, no increase in system y+L activity is observed.
GM-CSF Positive_regulation (induces) of Gene_expression (macrophages) of LPI in macrophages
3) Confidence 0.16 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.09 Pain Relevance 0

General Comments

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