INT349224

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A7) extracellular space (CSF2) extracellular region (CSF2)
plasma membrane (SLC7A7) protein complex assembly (SLC7A7) transmembrane transport (SLC7A7)
Anatomy Link Frequency
macrophage 1
CSF2 (Homo sapiens)
SLC7A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 35 93.92 High High
Systemic Lupus Erythematosus 1 15.24 Low Low
Leukocytosis 1 13.44 Low Low
Congenital Anomalies 2 12.44 Low Low
Respiratory Failure 5 5.00 Very Low Very Low Very Low
Pneumothorax 4 5.00 Very Low Very Low Very Low
Renal Disease 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Immunodeficiency 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that the presence of the mutated SLC7A7 does not interfere with the GM-CSF-induced macrophage differentiation and indicate that mechanisms other than impaired GM-CSF signalling should be investigated to explain LPI-associated PAP.
GM-CSF Neg (not) Binding (interfere) of SLC7A7 in macrophage associated with pulmonary alveolar proteinosis
1) Confidence 0.12 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.38 Pain Relevance 0

General Comments

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