INT349229

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.12
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TREM1) plasma membrane (TREM1) intracellular (TREM1)
Anatomy Link Frequency
monocytes 3
macrophages 1
fibroblasts 1
TREM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 15 58.56 Quite High
Angina 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 10 64.00 Quite High
Systemic Lupus Erythematosus 5 57.76 Quite High
Pulmonary Alveolar Proteinosis 175 5.00 Very Low Very Low Very Low
Respiratory Failure 25 5.00 Very Low Very Low Very Low
Pneumothorax 20 5.00 Very Low Very Low Very Low
Renal Disease 10 5.00 Very Low Very Low Very Low
Anaemia 5 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Immunodeficiency 5 5.00 Very Low Very Low Very Low
Interstitial Lung Diseases 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that in LPI monocytes and AM the mutation in SLC7A7 cannot be complemented by the low relative expression of SLC7A6.
Negative_regulation (complemented) of monocytes in monocytes
1) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Negative_regulation (pattern) of monocytes in monocytes
2) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Because of the genetic defect of SLC7A7/y+LAT1, the intracellular concentration of arginine is expected to be higher in LPI monocytes than in normal cells, although the scarce availability of the pathological samples prevents the quantification of arginine content in LPI monocytes/macrophages.
Negative_regulation (higher) of monocytes in monocytes
3) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.12 Pain Relevance 0.03
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Negative_regulation (pattern) of monocytes in macrophages
4) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Negative_regulation (pattern) of monocytes in fibroblasts
5) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0

General Comments

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