INT34923

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFS) Golgi apparatus (MTHFS) plasma membrane (MTHFS)
ligase activity (MTHFS) cytoplasm (MTHFS)
MTHFS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 100.00 Very High Very High Very High
aspirin 5 99.84 Very High Very High Very High
cINOD 8 87.80 High High
rheumatoid arthritis 1 81.76 Quite High
Pain 1 68.56 Quite High
Analgesic 1 59.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Prostate Cancer 9 99.48 Very High Very High Very High
Cancer 2 95.16 Very High Very High Very High
Rheumatoid Arthritis 1 81.76 Quite High
Disease 3 80.44 Quite High
Arthralgia 1 68.80 Quite High
Arthritis 1 65.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunosuppressive actions of prostaglandins and the possible increase in chronic inflammation after cyclo-oxygenase inhibitors.
Spec (possible) Positive_regulation (increase) of cyclo-oxygenase associated with inflammation
1) Confidence 0.49 Published 1986 Journal Agents Actions Section Title Doc Link 3099559 Disease Relevance 0.62 Pain Relevance 0.47
These findings lend support to proposed underlying aetiological hypotheses which imply a role for cyclo-oxygenase activity in prostate cancer progression.
Positive_regulation (role) of cyclo-oxygenase associated with prostate cancer
2) Confidence 0.45 Published 1998 Journal Int. J. Cancer Section Abstract Doc Link 9679750 Disease Relevance 0.70 Pain Relevance 0.31
It prevents the inhibition of cyclo-oxygenase induced by aspirin, but does not counteract the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on both enzymes.
Positive_regulation (induced) of cyclo-oxygenase associated with aspirin
3) Confidence 0.30 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6411131 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

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