INT349232

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LAT) intracellular (LAT)
Anatomy Link Frequency
macrophage 2
LAT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spontaneous Remission 2 93.96 High High
Pulmonary Alveolar Proteinosis 70 92.96 High High
Granuloma 2 82.72 Quite High
Leukocytosis 2 73.72 Quite High
Respiratory Failure 10 5.00 Very Low Very Low Very Low
Pneumothorax 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Renal Disease 4 5.00 Very Low Very Low Very Low
Anaemia 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, the link between GM-CSF, impaired y+LAT1 expression and surfactant accumulation in LPI remains to be elucidated, and our report is not conclusive, taking into consideration the single case and the possibility, although rare, of a spontaneous remission of PAP.
Positive_regulation (accumulation) of Gene_expression (expression) of LAT1 associated with pulmonary alveolar proteinosis and spontaneous remission
1) Confidence 0.27 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.58 Pain Relevance 0
Alternatively, GM-CSF-dependent increase of SLC7A7 mRNA may lead to an enhanced synthesis of y+LAT1 protein that ameliorates macrophage function.
Positive_regulation (enhanced) of Gene_expression (synthesis) of LAT1 in macrophage
2) Confidence 0.25 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.40 Pain Relevance 0

General Comments

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