INT349234

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 0.09
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A6) plasma membrane (SLC7A6) protein complex assembly (SLC7A6)
transmembrane transport (SLC7A6) cellular amino acid metabolic process (SLC7A6)
Anatomy Link Frequency
monocytes 7
macrophages 2
fibroblasts 2
SLC7A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 91.40 High High
Angina 14 5.00 Very Low Very Low Very Low
cva 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 490 87.20 High High
Congenital Anomalies 28 20.64 Low Low
Systemic Lupus Erythematosus 14 14.40 Low Low
Respiratory Failure 70 5.00 Very Low Very Low Very Low
Pneumothorax 56 5.00 Very Low Very Low Very Low
Renal Disease 28 5.00 Very Low Very Low Very Low
Anaemia 14 5.00 Very Low Very Low Very Low
Angina 14 5.00 Very Low Very Low Very Low
Immunodeficiency 14 5.00 Very Low Very Low Very Low
Interstitial Lung Diseases 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The comparison between SLC7A7 and SLC7A6 expression levels indicated that in normal monocytes SLC7A7 mRNA was 30-fold more expressed than SLC7A6 (0.021 ± 0.005 molecules SLC7A7/RPL15 vs 0.0007 ± 0.00004 molecules SLC7A6/RPL15).
Gene_expression (expression) of SLC7A6 in monocytes
1) Confidence 0.71 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
These data suggest that in LPI monocytes and AM the mutation in SLC7A7 cannot be complemented by the low relative expression of SLC7A6.
Gene_expression (expression) of SLC7A6 in monocytes
2) Confidence 0.71 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
The comparison between SLC7A7 and SLC7A6 expression levels indicated that in normal monocytes SLC7A7 mRNA was 30-fold more expressed than SLC7A6 (0.021 ± 0.005 molecules SLC7A7/RPL15 vs 0.0007 ± 0.00004 molecules SLC7A6/RPL15).
Gene_expression (expressed) of SLC7A6 in monocytes
3) Confidence 0.62 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
The comparison between SLC7A7 and SLC7A6 expression levels indicated that in normal monocytes SLC7A7 mRNA was 30-fold more expressed than SLC7A6 (0.021 ± 0.005 molecules SLC7A7/RPL15 vs 0.0007 ± 0.00004 molecules SLC7A6/RPL15).
Gene_expression (expressed) of SLC7A6 in monocytes
4) Confidence 0.62 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
The different transport phenotypes are referable to the relative levels of expression of SLC7A7 and SLC7A6.
Gene_expression (expression) of SLC7A6
5) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.09 Pain Relevance 0.04
Under the same conditions, the expression of SLC7A6 did not exhibit any significant change, both in normal and in LPI cells.


Gene_expression (expression) of SLC7A6
6) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.05
As far as system y+L activity is concerned, the different phenotype displayed by LPI monocytes/macrophages and fibroblasts can be explained by the relative level of expression of SLC7A7 and SLC7A6 in these models.
Gene_expression (expression) of SLC7A6 in monocytes
7) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.04
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of SLC7A6 in monocytes
8) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
SLC7A6, SLC7A7 and RPL15 expression levels are given as numbers of mRNA molecules [19].
Gene_expression (expression) of SLC7A6
9) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Hence, whereas a normal expression of SLC7A6/y+LAT2 can compensate for the mutation of SLC7A7/y+LAT1 in LPI fibroblasts, the prevailing expression of y+LAT1 in monocytes and AM explains the typical LPI tissue-specific transport defect in these cells.
Gene_expression (expression) of SLC7A6 in monocytes
10) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.04
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of SLC7A6 in fibroblasts
11) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
As far as system y+L activity is concerned, the different phenotype displayed by LPI monocytes/macrophages and fibroblasts can be explained by the relative level of expression of SLC7A7 and SLC7A6 in these models.
Gene_expression (expression) of SLC7A6 in fibroblasts
12) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.04
As far as system y+L activity is concerned, the different phenotype displayed by LPI monocytes/macrophages and fibroblasts can be explained by the relative level of expression of SLC7A7 and SLC7A6 in these models.
Gene_expression (expression) of SLC7A6 in macrophages
13) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.04
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of SLC7A6 in macrophages
14) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox