INT349238

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.11
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LAT) intracellular (LAT)
Anatomy Link Frequency
monocytes 2
macrophages 1
fibroblasts 1
LAT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 12 62.04 Quite High
Angina 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 8 57.04 Quite High
Systemic Lupus Erythematosus 4 50.80 Quite High
Pulmonary Alveolar Proteinosis 140 5.00 Very Low Very Low Very Low
Respiratory Failure 20 5.00 Very Low Very Low Very Low
Pneumothorax 16 5.00 Very Low Very Low Very Low
Renal Disease 8 5.00 Very Low Very Low Very Low
Anaemia 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Immunodeficiency 4 5.00 Very Low Very Low Very Low
Interstitial Lung Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the genetic defect of SLC7A7/y+LAT1, the intracellular concentration of arginine is expected to be higher in LPI monocytes than in normal cells, although the scarce availability of the pathological samples prevents the quantification of arginine content in LPI monocytes/macrophages.
Negative_regulation (defect) of LAT1 in monocytes
1) Confidence 0.23 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.11 Pain Relevance 0.03
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Negative_regulation (pattern) of LAT1 in monocytes
2) Confidence 0.23 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Negative_regulation (pattern) of LAT1 in macrophages
3) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Negative_regulation (pattern) of LAT1 in fibroblasts
4) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0

General Comments

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