INT349304

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 9.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PARK7) peptidase activity (PARK7) mitochondrion (PARK7)
mRNA binding (PARK7) mitochondrion organization (PARK7) nucleus (PARK7)
Anatomy Link Frequency
blood 3
plasma 1
brains 1
PARK7 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 40 5.00 Very Low Very Low Very Low
Substantia nigra 32 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
positron emission tomography 24 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Neuritis 8 5.00 Very Low Very Low Very Low
glial activation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 920 99.84 Very High Very High Very High
Stress 32 96.92 Very High Very High Very High
Neurodegenerative Disease 48 93.12 High High
Stroke 8 83.76 Quite High
Familial Amyloidotic Polyneuropathy 8 83.28 Quite High
Skin Cancer 8 81.80 Quite High
Breast Cancer 8 81.40 Quite High
Drug Induced Neurotoxicity 8 65.36 Quite High
Disease Progression 24 55.68 Quite High
Respiratory Failure 8 54.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Choi et al. reported that the total level of DJ-1 measured by semi-quantitative immunoblot analysis is significantly increased in PD and AD brains [32].
Positive_regulation (increased) of DJ-1 in brains associated with disease
1) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 1.57 Pain Relevance 0
Consistent with this, we observed that both monomer and aggregates of DJ-1 were abundantly present in the CSF, and our semi-quantitative immunoblot analysis revealed that CSF-1 DJ-1 monomer levels were significantly increased in PD compared to those in non-PD controls [33].
Positive_regulation (increased) of DJ-1 associated with disease
2) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 1.50 Pain Relevance 0
We also found that plasma DJ-1 levels were increased in PD cases compared to non-PD controls [34].
Positive_regulation (increased) of DJ-1 in plasma associated with disease
3) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 1.44 Pain Relevance 0
Hong et al. conducted a careful measurement of CSF DJ-1, as described above for CSF ?
Positive_regulation (measurement) of DJ-1
4) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 0.94 Pain Relevance 0
-synuclein and DJ-1 levels were substantially increased in all samples that were contaminated with blood (>200 ng/mL hemoglobin).
Positive_regulation (increased) of DJ-1 in blood
5) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 0.59 Pain Relevance 0
Our findings stimulated investigation of CSF and blood DJ-1 in the PD field, but the results obtained by other groups were variable and mostly contradictory to our data.
Positive_regulation (stimulated) of DJ-1 in blood associated with disease
6) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 1.37 Pain Relevance 0
Examination of the oxidized DJ-1 levels could be more meaningful because abnormal oxidized DJ-1 has been specifically increased in patients with PD and AD [32,37] and measurement of oxidized DJ-1 in the CSF or blood using these specific DJ-1 antibodies with Western blot and ELISA system could be useful.


Positive_regulation (increased) of DJ-1 in blood associated with disease
7) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 1.18 Pain Relevance 0
These findings led to the conclusion that total DJ-1 and ?
Positive_regulation (total) of DJ-1
8) Confidence 0.42 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 0.86 Pain Relevance 0

General Comments

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