INT34936

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.85
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 7
leucocyte 3
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 84 99.98 Very High Very High Very High
cINOD 43 99.98 Very High Very High Very High
Angina 2 98.32 Very High Very High Very High
Inflammation 13 96.24 Very High Very High Very High
Pain 3 95.56 Very High Very High Very High
COX-2 inhibitor 15 90.36 High High
diclofenac 1 88.00 High High
agonist 1 86.16 High High
ischemia 1 77.72 Quite High
iatrogenic 1 64.44 Quite High
Disease Link Frequency Relevance Heat
Bacterial Infection 40 99.52 Very High Very High Very High
Syndrome 1 98.86 Very High Very High Very High
Cv General 3 Under Development 6 98.32 Very High Very High Very High
INFLAMMATION 20 96.24 Very High Very High Very High
Pain 3 95.56 Very High Very High Very High
Increased Venous Pressure Under Development 6 92.96 High High
Injury 2 89.48 High High
Solid Tumor 1 85.28 High High
Myocardial Infarction 20 83.20 Quite High
Stroke 10 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unstable angina may be a clinical syndrome in which these events occur, which can be alleviated by inhibition of platelet activation and TXA2 formation with aspirin.
Negative_regulation (inhibition) of TXA2 Binding (formation) of in platelet associated with aspirin, angina and syndrome
1) Confidence 0.44 Published 1987 Journal Fed. Proc. Section Abstract Doc Link 3100342 Disease Relevance 0.46 Pain Relevance 0.15
Trapidil has shown a more complete antithrombocytic activity than other antiaggregating drugs; as a matter of fact it inhibits the formation of TXA2 through a mechanism of receptorial antagonism and at the same time it favours an increase of prostacyclina from the arterial walls.
Negative_regulation (inhibits) of TXA2 Binding (formation) of
2) Confidence 0.34 Published 1993 Journal Minerva Cardioangiol Section Abstract Doc Link 8373465 Disease Relevance 0.28 Pain Relevance 0.09
They do not reduce the formation of the COX-1-derived thromboxane A2 (TXA2), however, which is both atherogenic and a potent vasoconstrictor.
Neg (not) Negative_regulation (reduce) of TXA2 Neg (not) Binding (formation) of
3) Confidence 0.27 Published 2005 Journal Trends Endocrinol. Metab. Section Abstract Doc Link 15950485 Disease Relevance 0.42 Pain Relevance 0.22
Among these drugs picotamide attracted the attention of researchers for its ability to inhibit both TxA2 platelet synthase and platelet TxA2 receptors and, in turn, platelet aggregation.
Negative_regulation (inhibit) of TxA2 Binding (receptors) of in platelet
4) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.08 Pain Relevance 0.20
Ibuprofen prevents the formation of TxA2, as well as platelet and leucocyte aggregation [12,21].
Negative_regulation (prevents) of TxA2 Binding (formation) of in leucocyte
5) Confidence 0.07 Published 2002 Journal BMC Infect Dis Section Body Doc Link PMC137589 Disease Relevance 0.57 Pain Relevance 0.03
Aspirin inhibits activation of the enzyme cyclooxygenase and thus cyclooxygenase-dependent formation of autoactivating TxA2 in platelets (Figure 2).
Negative_regulation (inhibits) of TxA2 Binding (formation) of in platelets associated with aspirin
6) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0.21 Pain Relevance 0.24
In contrast, NSAIDs reduce formation of both prostacyclin and thromboxane A2, with individual drugs differing in their relative blockade of COX-1 and COX-2 activities.
Negative_regulation (reduce) of thromboxane A2 Binding (formation) of associated with cinod
7) Confidence 0.04 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.27 Pain Relevance 0.40
Ibuprofen prevents the formation of TxA2, as well as platelet and leucocyte aggregation [12,21].
Negative_regulation (prevents) of TxA2 in platelet Binding (formation) of in leucocyte
8) Confidence 0.02 Published 2002 Journal BMC Infect Dis Section Body Doc Link PMC137589 Disease Relevance 0.57 Pain Relevance 0.03

General Comments

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