INT349488

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 12 90.20 High High
cytokine 8 76.96 Quite High
Inflammation 42 75.44 Quite High
cINOD 27 73.36 Quite High
Inflammatory stimuli 2 56.08 Quite High
Inflammatory response 1 42.80 Quite Low
Inflammatory mediators 4 35.28 Quite Low
Dopamine 21 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 108 100.00 Very High Very High Very High
Aging 18 98.64 Very High Very High Very High
Disease 35 96.52 Very High Very High Very High
Stress 1 82.28 Quite High
INFLAMMATION 52 75.44 Quite High
Apoptosis 1 63.84 Quite High
Drug Induced Neurotoxicity 10 53.84 Quite High
Death 2 50.28 Quite High
Toxicity 15 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, ageing mice fed with a control diet exhibited a dramatic increase of 3-NT colocalization with TH+ neurons by 3 d after MPTP, corresponding to the active DAergic degeneration phase [27,28,32,33,36], while by 7 d a certain decrease in 3-NT accumulation within TH+ neurons was observed, possibly indicating the end of the degeneration phase.
Positive_regulation (accumulation) of Localization (colocalization) of TH in neurons associated with parkinson's disease and aging
1) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.96 Pain Relevance 0.34

General Comments

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