INT349504

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ptpn2, Th) cytoplasm (Ptpn2, Th) cytosol (Th)
phosphatase activity (Ptpn2) mitochondrion (Th) oxidoreductase activity (Th)
Ptpn2 (Mus musculus)
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 42 92.56 High High
monoamine 4 64.72 Quite High
Eae 2 56.24 Quite High
Inflammation 84 50.00 Quite Low
cINOD 54 5.00 Very Low Very Low Very Low
midbrain 24 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 216 100.00 Very High Very High Very High
Toxicity 30 96.44 Very High Very High Very High
Drug Induced Neurotoxicity 20 93.56 High High
Aging 36 55.96 Quite High
INFLAMMATION 104 50.00 Quite Low
Disease 70 8.68 Low Low
Injury 12 5.00 Very Low Very Low Very Low
Experimental Autoimmune Encephalomyelitis 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Multiple Sclerosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels
MPTP Negative_regulation (loss) of TH associated with parkinson's disease
1) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.70 Pain Relevance 0.16
In mice fed with a control diet, MPTP induced a dose-dependent loss of double-stained TH+ (revealed by FITC, in green) DAT+ (revealed by CY3, in red) cells in SNpc (compare Figure 4A, B and 4C with Figure 4D, E and 4F), whereas MPTP-induced DAergic neurotoxicity was signicantly (p < 0.05) reduced in HCT1026-fed mice (Figure 4G, H and 4I).
MPTP Negative_regulation (loss) of TH associated with parkinson's disease and drug induced neurotoxicity
2) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.30 Pain Relevance 0.03

General Comments

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