INT349505

Context Info Confidence 0.19 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.70 Pain Relevance 0.16

phosphatase activity (Ptpn2) transport (Slc6a3) endoplasmic reticulum (Ptpn2) plasma membrane (Slc6a3) nucleus (Ptpn2) transmembrane transport (Slc6a3)

Ptpn2 (Mus musculus) Slc6a3 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 21 93.20 Eae 1 56.24 Inflammation 42 50.00 cINOD 27 5.00 midbrain 12 5.00 cytokine 8 5.00 Inflammatory mediators 4 5.00 COX-2 inhibitor 3 5.00 agonist 3 5.00 glial activation 2 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 108 100.00 INFLAMMATION 52 50.00 Aging 18 38.72 Disease 35 8.68 Toxicity 15 5.00 Drug Induced Neurotoxicity 10 5.00 Injury 6 5.00 Experimental Autoimmune Encephalomyelitis 2 5.00 Death 2 5.00 Multiple Sclerosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels

MPTP Negative_regulation (loss) of DAT associated with parkinson's disease

1) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.70 Pain Relevance 0.16

General Comments

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