INT34952

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 28
Total Number 33
Disease Relevance 6.05
Pain Relevance 14.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
brain 5
epithelium 3
oocyte 2
outflow 1
neural 1
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 681 100.00 Very High Very High Very High
Glutamate 75 100.00 Very High Very High Very High
Neurotransmitter 33 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
GABA receptor 6 100.00 Very High Very High Very High
Somatostatin 5 100.00 Very High Very High Very High
Opioid 5 99.92 Very High Very High Very High
anticonvulsant 17 99.56 Very High Very High Very High
Lamotrigine 14 99.36 Very High Very High Very High
noradrenaline 2 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 206 100.00 Very High Very High Very High
Stress 102 99.90 Very High Very High Very High
Overactive Bladder 12 99.16 Very High Very High Very High
Manic Depressive Disorder 22 98.56 Very High Very High Very High
Anxiety Disorder 40 98.20 Very High Very High Very High
Convulsion 32 98.16 Very High Very High Very High
Intellectual Impairment 3 97.80 Very High Very High Very High
Epilepsy 27 97.36 Very High Very High Very High
Disease 87 96.36 Very High Very High Very High
Post-traumatic Stress Disorder 88 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, patients with DRPLA might have decreased GABA in the basal ganglia, and anesthetics would affect GABA receptors.
Regulation (affect) of GABA in basal ganglia associated with gaba and gaba receptor
1) Confidence 0.61 Published 2002 Journal Masui Section Abstract Doc Link 12058442 Disease Relevance 0.74 Pain Relevance 0.46
However, there are few reports concerning the effects of the oral administration of GABA on temperature regulation in humans during rest and exercise.
Regulation (effects) of GABA associated with gaba
2) Confidence 0.39 Published 2009 Journal Osaka City Med J Section Abstract Doc Link 20088409 Disease Relevance 0 Pain Relevance 0.23
Effect of oral administration of GABA on temperature regulation in humans during rest and exercise at high ambient temperature.
Regulation (Effect) of GABA associated with gaba
3) Confidence 0.39 Published 2009 Journal Osaka City Med J Section Title Doc Link 20088409 Disease Relevance 0 Pain Relevance 0.23
Our data suggest that the previously reported animal studies on the central suppressive effect of GABA on endogenous LRH release is less prominent than the suppressive effect of opioidergic regulatory mechanisms in the human male.
Regulation (effect) of GABA associated with gaba
4) Confidence 0.34 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3102338 Disease Relevance 0 Pain Relevance 0.29
To our knowledge, there has been no prior assessment of expression of GABA transporters or of GABA catabolism enzymes in the human airway epithelium.
Regulation (assessment) of GABA in epithelium associated with gaba
5) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.06 Pain Relevance 0.56
To our knowledge, there has been no prior assessment of expression of GABA transporters or of GABA catabolism enzymes in the human airway epithelium.
Regulation (assessment) of GABA in epithelium associated with gaba
6) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.06 Pain Relevance 0.56
Independent of smoking status, the only GABA synthesis enzymes expressed in the large airway epithelium and small airway epithelium was GAD67.
Regulation (Independent) of GABA in epithelium associated with gaba and nicotine addiction
7) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.39 Pain Relevance 0.57
Our results indicate that propofol has an impact on the levels of neurotransmitters such as NAA, GLU, GABA and Cho in normal human brain.
Regulation (impact) of GABA in brain associated with gaba, glutamate and neurotransmitter
8) Confidence 0.28 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19853639 Disease Relevance 0.34 Pain Relevance 0.73
At high concentrations (>1.5mM) (+)- and (-)-borneol directly activated GABA(A) receptors producing 89% and 84%, respectively, of the maximal GABA response indicative of a weak partial agonist action.
Spec (partial) Regulation (response) of GABA associated with gaba and agonist
9) Confidence 0.27 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763546 Disease Relevance 0 Pain Relevance 0.63
Some of the new anticonvulsants, in particular those affecting the gamma-aminobutyric acid (GABA) system such as vigabatrin, seem to exacerbate this problem and should be used with caution in these patients.
Regulation (affecting) of GABA associated with gaba and anticonvulsant
10) Confidence 0.24 Published 2000 Journal Drugs Section Abstract Doc Link 10929928 Disease Relevance 0.47 Pain Relevance 0.34
Modulation of cerebral GABA by topiramate, lamotrigine, and gabapentin in healthy adults.
Regulation (Modulation) of GABA associated with gaba, lamotrigine and gabapentin
11) Confidence 0.24 Published 2002 Journal Neurology Section Title Doc Link 11839834 Disease Relevance 0 Pain Relevance 0.34
At high concentrations (>1.5mM) (+)- and (-)-borneol directly activated GABA(A) receptors producing 89% and 84%, respectively, of the maximal GABA response indicative of a weak partial agonist action.
Spec (partial) Regulation (response) of GABA associated with gaba and agonist
12) Confidence 0.24 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763546 Disease Relevance 0 Pain Relevance 0.62
As measured by high-performance liquid chromatography, only GABA but not glutamate outflow was affected by HFS/veratridine stimulation.
Regulation (affected) of GABA in outflow associated with glutamate and gaba
13) Confidence 0.18 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 19296090 Disease Relevance 0 Pain Relevance 0.81
Our data support this conclusion, as only SP duration was affected in our patient population, presumably through GABA-b receptors, whereas short ICI was normal.
Regulation (affected) of GABA associated with gaba
14) Confidence 0.16 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.13 Pain Relevance 0.46
At alpha1beta2gamma2s receptors, norbiphen had no affect on the GABA reversal potential, and inhibition was not voltage-dependent, suggesting that this compound does not act at the ion channel.
Neg (no) Regulation (affect) of GABA associated with gaba
15) Confidence 0.14 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12367622 Disease Relevance 0.06 Pain Relevance 0.59
Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms.
Regulation (Modulation) of GABA associated with gaba
16) Confidence 0.13 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 10066142 Disease Relevance 0.09 Pain Relevance 0.45
It is important to note that the spatial and temporal patterns of responses in primary somatosensory cortex (SI) to repetitive vibrotactile stimulation are largely dependent on the complex interplay of GABA-mediated inhibition [13] and NMDAR activation [14] in addition to other neural processes [15,16].
Regulation (dependent) of GABA in neural associated with gaba and primary somatosensory cortex
17) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553799 Disease Relevance 0 Pain Relevance 0.33
Potentially, drugs affecting GABA, opioid, 5-HT, noradrenaline, dopamine, or glutamatergic receptors and mechanisms can be developed, but a selective action on the lower urinary tract may be difficult to obtain.
Regulation (affecting) of GABA in lower urinary tract associated with dopamine, gaba, noradrenaline and opioid
18) Confidence 0.10 Published 1999 Journal Exp. Physiol. Section Abstract Doc Link 10081718 Disease Relevance 0.49 Pain Relevance 0.54
In order to study the influence of subunit subtypes of the GABA(A) receptor on modulation of receptor function by neuroactive steroids, we expressed human recombinant GABA(A) receptors in Xenopus oocytes.
Regulation (influence) of GABA in oocytes associated with gaba
19) Confidence 0.09 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10066142 Disease Relevance 0.10 Pain Relevance 0.44
GABA, somatostatin and enkephalin are neurotransmitters of enteric interneurons and comprise part of the intrinsic neural circuits regulating peristalsis.
Regulation (regulating) of GABA in interneurons associated with neurotransmitter, gaba, somatostatin and enkephalin
20) Confidence 0.08 Published 1998 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 9531443 Disease Relevance 0 Pain Relevance 0.50

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox