INT349530

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Smcp) extracellular space (Tnfsf10) cytoplasm (Smcp)
Tnfsf10 (Mus musculus)
Smcp (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 4 47.56 Quite Low
agonist 1 46.96 Quite Low
antagonist 1 40.88 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 48 95.96 Very High Very High Very High
Melanoma 63 91.12 High High
Toxicity 5 77.44 Quite High
Cancer 33 22.48 Low Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Carcinoma 2 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the above, we postulate the following working model for anti-MCSP:TRAIL (see also Figure 6B); anti-MCSP:TRAIL binds to MCSP and inhibits MCSP-signaling, which includes inhibition of src-kinases and FAK, the STAT transcription factors, and various anti-apoptotic modulators such as p53, TOR, JNK.
TRAIL Negative_regulation (inhibits) of MCSP-signaling associated with apoptosis
1) Confidence 0.28 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.88 Pain Relevance 0

General Comments

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