INT349532

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf10) mitochondrion (Smcp) cytoplasm (Smcp)
Anatomy Link Frequency
melanocytes 2
Smcp (Mus musculus)
Tnfsf10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 11.56 Low Low
fortral 8 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 96 100.00 Very High Very High Very High
Malignant Neoplastic Disease 8 99.84 Very High Very High Very High
Toxicity 10 97.76 Very High Very High Very High
Cancer 66 94.88 High High
Melanoma 126 87.84 High High
Carcinoma 4 63.12 Quite High
Death 4 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, although anti-MCSP:TRAIL strongly bound to MCSP on normal human melanocytes (Additional file 1, Figure S1D), no apoptosis was induced in melanocytes even when treatment was performed with 4 ?
Positive_regulation (induced) of MCSP Binding (bound) of TRAIL in melanocytes associated with apoptosis
1) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.95 Pain Relevance 0
Thus, anti-MCSP:TRAIL activity is strictly dependent on binding to cell surface-expressed MCSP on malignant cells.
Positive_regulation (dependent) of MCSP Binding (binding) of TRAIL associated with malignant neoplastic disease
2) Confidence 0.30 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox