INT349535

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 6.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf10) mitochondrion (Smcp) cytoplasm (Smcp)
Anatomy Link Frequency
melanocytes 1
Smcp (Mus musculus)
Tnfsf10 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 32 47.56 Quite Low
agonist 8 46.96 Quite Low
cytokine 24 41.88 Quite Low
antagonist 8 40.88 Quite Low
metalloproteinase 8 13.12 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 384 99.98 Very High Very High Very High
Cancer 264 99.98 Very High Very High Very High
Malignant Neoplastic Disease 32 99.84 Very High Very High Very High
Melanoma 504 99.04 Very High Very High Very High
Toxicity 40 97.76 Very High Very High Very High
Leukemia 8 72.24 Quite High
Carcinoma 16 71.16 Quite High
Glioma 8 56.72 Quite High
Breast Cancer 8 55.84 Quite High
Necrosis 8 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, although anti-MCSP:TRAIL strongly bound to MCSP on normal human melanocytes (Additional file 1, Figure S1D), no apoptosis was induced in melanocytes even when treatment was performed with 4 ?
MCSP Binding (bound) of TRAIL in melanocytes associated with apoptosis
1) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.94 Pain Relevance 0
Taken together, these data clearly demonstrate that the pro-apoptotic activity of anti-MCSP:TRAIL is TRAIL-mediated.
anti-MCSP Binding (activity) of TRAIL-mediated associated with apoptosis
2) Confidence 0.28 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.56 Pain Relevance 0
Taken together, these data clearly demonstrate that the pro-apoptotic activity of anti-MCSP:TRAIL is TRAIL-mediated.
anti-MCSP Binding (activity) of TRAIL associated with apoptosis
3) Confidence 0.28 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.55 Pain Relevance 0
Together, these experimental data suggest that the simultaneous interaction of anti-MCSP:TRAIL with MCSP and TRAIL-receptors uniquely blocks anchorage-independent growth of melanoma cells at low concentrations.


anti-MCSP Binding (interaction) of TRAIL associated with melanoma
4) Confidence 0.27 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.32 Pain Relevance 0
Anti-MCSP:TRAIL was designed to selectively bind to MCSP at the cell surface of melanoma cells and simultaneously inhibit tumorigenic signaling by MCSP.
MCSP Binding (bind) of TRAIL associated with melanoma
5) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.60 Pain Relevance 0
Based on the above, we postulate the following working model for anti-MCSP:TRAIL (see also Figure 6B); anti-MCSP:TRAIL binds to MCSP and inhibits MCSP-signaling, which includes inhibition of src-kinases and FAK, the STAT transcription factors, and various anti-apoptotic modulators such as p53, TOR, JNK.
MCSP Binding (binds) of TRAIL associated with apoptosis
6) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.82 Pain Relevance 0
Thus, anti-MCSP:TRAIL activity is strictly dependent on binding to cell surface-expressed MCSP on malignant cells.
MCSP Binding (binding) of TRAIL associated with malignant neoplastic disease
7) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.21 Pain Relevance 0
Anti-tumor activity of low dose anti-MCSP:TRAIL towards A375M xenografts
anti-MCSP Binding (activity) of TRAIL associated with cancer
8) Confidence 0.21 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.79 Pain Relevance 0

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