INT349537

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.48
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf10) mitochondrion (Smcp) cytoplasm (Smcp)
Smcp (Mus musculus)
Tnfsf10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 97.96 Very High Very High Very High
fortral 12 92.04 High High
agonist 3 91.44 High High
antagonist 3 85.36 High High
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 189 100.00 Very High Very High Very High
Apoptosis 144 100.00 Very High Very High Very High
Toxicity 15 99.08 Very High Very High Very High
Cancer 99 89.92 High High
Death 6 89.76 High High
Malignant Neoplastic Disease 12 76.16 Quite High
Breast Cancer 3 74.16 Quite High
Glioma 3 73.44 Quite High
Leukemia 3 21.96 Low Low
Carcinoma 6 20.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MCSP-restricted induction of apoptosis by anti-MCSP:TRAIL
anti-MCSP Positive_regulation (induction) of TRAIL associated with apoptosis
1) Confidence 0.38 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.65 Pain Relevance 0.05
Rimcazole did not upregulate TRAIL-R1 or TRAIL-R2 expression (data not shown), but augmented the activation of initiator caspase-8 and initiator caspase-9 upon anti-MCSP:TRAIL treatment (Additional file 3, Figure S2A and B, respectively).
anti-MCSP Neg (not) Positive_regulation (augmented) of TRAIL
2) Confidence 0.38 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.68 Pain Relevance 0.18
Anti-MCSP:TRAIL was designed to 1. selectively accrete at the cell surface of MCSP-positive melanoma cells and inhibit MCSP tumorigenic signaling and 2. activate apoptotic TRAIL-signaling.


Anti-MCSP Positive_regulation (activate) of TRAIL-signaling associated with melanoma and apoptosis
3) Confidence 0.35 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC3000402 Disease Relevance 1.15 Pain Relevance 0.05

General Comments

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