INT349553

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
neuronal 2
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Gabapentin 1 88.28 High High
c fibre 20 71.24 Quite High
Spinal cord 27 64.28 Quite High
Pain 5 46.16 Quite Low
Lasting pain 6 42.20 Quite Low
Neurotransmitter 2 39.36 Quite Low
Neuropathic pain 8 30.60 Quite Low
wide dynamic range 11 5.00 Very Low Very Low Very Low
Dorsal horn 7 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 25 98.40 Very High Very High Very High
Nervous System Injury 13 98.20 Very High Very High Very High
Neuropathic Pain 17 87.64 High High
Nociception 8 50.64 Quite High
Pain 11 46.16 Quite Low
Cancer 2 29.92 Quite Low
Injury 5 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies showed that selective mTOR inhibitors such as rapamycin attenuate the neuronal plasticity and behavioral hypersensitivity associated with formalin by inhibiting mRNA translation since they exert the same effects as the global mRNA translation inhibitor anisomycin.1 Therefore, we are confident that CCI-779 acts specifically by inhibiting mTOR signaling pathways.
Negative_regulation (attenuate) of Negative_regulation (inhibitors) of mTOR in neuronal associated with hypersensitivity
1) Confidence 0.40 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.67 Pain Relevance 0.19

General Comments

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