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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
neuronal 1
Olr779 (Rattus norvegicus)
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Gabapentin 1 77.20 Quite High
c fibre 20 60.16 Quite High
Spinal cord 27 53.20 Quite High
Pain 5 35.08 Quite Low
Lasting pain 6 31.12 Quite Low
Neurotransmitter 2 28.28 Quite Low
Neuropathic pain 8 19.52 Low Low
wide dynamic range 11 5.00 Very Low Very Low Very Low
Dorsal horn 7 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 25 96.44 Very High Very High Very High
Nervous System Injury 13 87.12 High High
Neuropathic Pain 17 76.56 Quite High
Cancer 2 52.16 Quite High
Nociception 8 39.56 Quite Low
Pain 11 35.08 Quite Low
Syndrome 2 21.60 Low Low
Injury 5 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies showed that selective mTOR inhibitors such as rapamycin attenuate the neuronal plasticity and behavioral hypersensitivity associated with formalin by inhibiting mRNA translation since they exert the same effects as the global mRNA translation inhibitor anisomycin.1 Therefore, we are confident that CCI-779 acts specifically by inhibiting mTOR signaling pathways.
CCI-779 Negative_regulation (inhibiting) of mTOR in neuronal associated with hypersensitivity
1) Confidence 0.02 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.50 Pain Relevance 0.16

General Comments

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